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Title: Homo sapiens : Homo sapiens Raw sequence reads      
keywords:
raw sequence reads
ID:
PRJNA324255
description:
Our study focuses on gliomas, the most common primary brain tumors in adults, and understanding the role of endogenous transposable elements in these malignancies. Using genomic DNA from 7 low passage oncosphere cell lines derived from primary GBM biopsies, 3 secondary GBM tissue samples, and matched normal blood samples, we performed transposon insertion profiling by deep sequencing (TIPseq) of the active subfamily of Long INterspered Element-1 (LINE-1) elements to find evidence of somatic retrotransposition. Our findings indicate that although LINE-1 can act as an infrequent insertional mutagen in secondary glioblastomas, retrotransposition is uncommon in these central nervous system tumors as compared to other neoplasias.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA324255
authentication:
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authorization:
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name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject