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Title: Epigenetic reprogramming in naïve CD4+ T cells favoring T cell activation and Th2 differentiation as an early event in lupus flares      
keywords:
Epigenomics
ID:
PRJNA319260
description:
Systemic lupus erythematosus is a relapsing autoimmune disease that affects multiple organ systems. T cells play an important role in the pathogenesis of lupus, however, early T cell events triggering disease flares are incompletely understood. We studied DNA methylation in naïve CD4+ T cells from lupus patients to determine if epigenetic landscape change in CD4+ T cells is an early event in lupus flares. Overall design: A total of 74 lupus patients with disease activity ranging from 0-18 as measured by the systemic lupus erythematosus disease activity index (SLEDAI) were included in this study. Naïve CD4+ T cells were isolated from peripheral blood samples and DNA extracted for genome-wide methylation assessment. RNA was also extracted from a subset of patients to determine the relationship between epigenetic changes and transcriptional activity using RNA sequencing.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA319260
authentication:
none
authorization:
none
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject