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Title: Polycomb-mediated deactivation of AR-feedback loop leads to castration-resistant prostate cancer [gene expression]      
keywords:
Transcriptome or Gene expression
ID:
PRJNA315573
description:
Castration-resistant prostate cancer (CRPC) is a lethal disease, often characterized by aberrant androgen receptor (AR) activation independently of androgen. We have previously reported that AR can directly repress the expression of many target genes, one of which is NOV/CCN3. Here we show that NOV, primarily localized in the cytoplasm, physically interacts with AR at its Nterminus and sequesters AR and AR variants in the cytoplasm, thereby reducing AR chromatintargeting. This negative feedback loop, however, is disrupted in CRPC due to epigenetic silencing of NOV by the Polycomb group protein EZH2, rendering AR transcriptional activities and drug-resistant prostate cancer progression. Our findings thus suggest a working model wherein AR-repressed genes critically prevent CRPC through negative feedback loops inhibiting AR signaling. Overall design: genetic_modification_design; gene expression of LNCaP or C42B cells
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA315573
authentication:
none
authorization:
none
ID:
pmid:27815387
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • P50 CA180995/CA/NCI NIH HHS/United States

  • R50 CA211271/CA/NCI NIH HHS/United States

  • T32 CA009560/CA/NCI NIH HHS/United States

  • R01 CA172384/CA/NCI NIH HHS/United States

  • T32 DK007169/DK/NIDDK NIH HHS/United States

  • P30 CA060553/CA/NCI NIH HHS/United States

  • T32 CA080621/CA/NCI NIH HHS/United States

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