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Title: PsychENCODE Consortium: Autism Post-Mortem Brain RNA-Sequencing - Global changes in patterning, splicing and lncRNAs      
keywords:
Phenotype or Genotype
ID:
PRJNA308995
description:
Autism spectrum disorder (ASD) is a neurodevelopmental syndrome characterized by deficits in social communication and mental flexibility. Genetic risk factors contribute substantially to ASD risk, and recent studies support the potential contribution of more than a thousand genes to ASD risk. However, given the shared cognitive and behavioral features across the autism spectrum, one hypothesis is that diverse risk factors may converge on common molecular, cellular, and circuit level pathways to result in the shared phenotype. Analysis of the transcriptome has been used to identify common molecular pathways in the neocortex (CTX) from postmortem human brain tissue in individuals with ASD. However, all transcriptomic studies in ASD to date have been limited to evaluating highly expressed mRNAs corresponding to protein coding genes. Moreover, most lack rigorous replication and do not assess gene expression patterns across brain regions. We apply transcriptome... (for more see dbGaP study page.)
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA308995
authentication:
none
authorization:
none
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject