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Title: Chlamydomonas reinhardtii strain:CC-503 : chlamydomonas reinhardtii transcriptome      
keywords:
transcriptome
ID:
PRJNA298517
description:
Relationships between shared phylogenetic profiles and gene functions have been previously described; however, dynamics of conservation between genes remains incompletely characterized with respect to network topology and functional connectivity. Chlamydomonas reinhardtii, a green alga that has retained key genes with plant, animal, and protist affinities, serves as an ideal model organism to further investigate the interplay between gene function and phylogenetic affinities. Here, using detailed topological and functional network analyses, we show that network connectivity has a significant concordance with the co-conservation of genes in the C. reinhardtii metabolic network while a distinction between topological and functional relationships is observable. Dynamic and static modes of co-conservation were defined and observed in a subset of gene-pairs across the network topologically. In contrast, genes with predicted synthetic interactions, or genes involved in coupled reactions, show significant enrichment for both shorter and longer phylogenetic distances. Based on our results, we propose that the metabolic network of C. reinhardtii is assembled with an architecture to minimize phylogenetic profile distances topologically, while it includes an expansion of such distances for functionally interacting genes. This arrangement may increase the robustness of C. reinhardtii’s network in dealing with varied environmental challenges that the species may face.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA298517
authentication:
none
authorization:
none
ID:
pmid:27357594
name:
Chlamydomonas reinhardtii
ncbiID:
ncbitax:3055
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject