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Title: Chromatin Remodeler CHD7 mutated in CHARGE Syndrome Interacts with Sox10 to Regulate Timing of CNS Myelination and Remyelination [RNA-seq]      
keywords:
Transcriptome or Gene expression
ID:
PRJNA294769
description:
Mutations in CHD7, encoding ATP-dependent chromodomain-helicase-DNA-binding protein 7, in CHARGE syndrome leads to multiple congenital anomalies including growth retardation, craniofacial malformations and neurological dysfunction. Currently, mechanisms underlying the CNS phenotypes remain poorly understood. Here, we show that Chd7 is a direct transcriptional target of oligodendrogenesis-promoting factors Olig2 and Brg1 and required for proper timing of CNS myelination and remyelination. Genome-occupancy analyses coupled with transcriptome profiling reveal that Chd7 cooperates with Sox10 to target the enhancers of key myelinogenic genes, and identify novel Chd7 target. Overall design: 4 RNA-Seq samples from P8 spinal cords of Ctrl and Chd7 cKO mice (duplicatess, Ctrl and cKO)
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA294769
authentication:
none
authorization:
none
ID:
pmid:26928066
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • R01 NS072427/NS/NINDS NIH HHS/United States

  • R01 NS078092/NS/NINDS NIH HHS/United States

  • R01 NS075243/NS/NINDS NIH HHS/United States

  • R01 DC009410/DC/NIDCD NIH HHS/United States

  • P30 DC005188/DC/NIDCD NIH HHS/United States

  • R37 NS096359/NS/NINDS NIH HHS/United States

  • UL1 TR001425/TR/NCATS NIH HHS/United States

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