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Title: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]      
keywords:
Transcriptome or Gene expression
ID:
PRJNA248916
description:
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Overall design: Male mice were exposed to low-dose penicillin (6.7 mg/L), from birth. Ileums were collected at 8 weeks of age, RNA was extracted, and transcriptional differences were measured by microarray analysis.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA248916
authentication:
none
authorization:
none
ID:
pmid:25126780
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • R01 AI093811/AI/NIAID NIH HHS/United States

  • P30 CA016087/CA/NCI NIH HHS/United States

  • UL1 RR029893/RR/NCRR NIH HHS/United States

  • R01 DK 090989/DK/NIDDK NIH HHS/United States

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