biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Son Maintains Accurate Splicing of Pre-mRNAs Encoding Chromatin Modifiers
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| keywords: |
Transcriptome or Gene expression
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| ID: |
PRJNA138951
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| description: |
Exon and expression analysis of HeLa cells after knockdown of SON
Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. Our laboratory recently showed that a large SR protein called Son has unique repeat motifs that are essential for maintaining the subnuclear organization of pre-mRNA processing factors in nuclear speckles. Motif analysis of Son highlights putative RNA interaction domains that suggest a direct role for Son in pre-mRNA splicing. A genome-wide screen was performed to identify putative human transcription and splicing targets of Son.
Overall design: HeLa cells were transfected with siRNA against SON or a control siRNA (siLuciferase) for 48 hours. Five biological replicates were used for each condition.
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| accesstypes: |
download
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| landingpage: | http://www.ncbi.nlm.nih.gov/bioproject/PRJNA138951 |
| authentication: |
none
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| authorization: |
none
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| ID: |
pmid:22193954
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| name: |
Homo sapiens
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| ncbiID: |
ncbitax:9606
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| abbreviation: |
NCBI
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| homePage: | http://www.ncbi.nlm.nih.gov |
| ID: |
SCR:006472
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| name: |
National Center for Biotechnology Information
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| homePage: | http://www.ncbi.nlm.nih.gov/bioproject |
| ID: |
SCR:004801
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| name: |
NCBI BioProject
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