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Title: Orthomyxoviridae      
ID:
PRJNA16888
description:
Description of Orthomyxoviridae adapted from ICTVdb Virion Properties Morphology Virions consist of an envelope, a matrix protein, a nucleoprotein complex, a nucleocapsid, and a polymerase complex. Virus capsid is enveloped. Virions are spherical to pleomorphic; filamentous forms occur. Virions measure 80-120 nm in diameter; 200-300(-3000) nm in length. Surface projections are densely dispersed distinctive hemagglutinin-esterase (HEF) spikes, or spaced widely apart hemagglutinin (HA) spikes. The major glycoprotein is interposed irregularly by clusters of neuraminidase (NA)in a ratio of HA to NA about 4-5 to 1. About 500 spikes evenly dispersed, or clustered are covering the surface comprise hemagglutinin, or neuraminidase, or esterase-esterase. Surface projections are composed of one type of protein, or different types of proteins and are 10-14 nm long; 4-6 nm in diameter. Capsid/nucleocapsid is elongated with helical symmetry. The nucleocapsid is helical; and segments have different size classes with clear predominate lengths with a length of 50-130 nm (in different size classes) and a width of 9-15 nm. The nucleocapsids are segmented with loops at one end. Physicochemical and Physical Properties The molecular mass (Mr) of virions is 250 x 106. Virions have a buoyant density in sucrose of 1.17-1.2 g cm-3. The sedimentation coefficient is 700-800 S20w (for non-filamentous particles). Virions are very sensitive. Virions are sensitive to treatment with heat, lipid solvents, non-ionic detergents, formaldehyde, oxidizing agents. The infectivity is reduced after exposure to irradiation. Nucleic Acid The genome is segmented and consists of six segments of to eight segments of linear, negative-sense, single-stranded RNA. The complete genome is 10000-14600 nucleotides long. The segment 1 is fully sequenced, complete sequence is 2300-2500 nucleotides long. Segment 2 is sequenced, but only an estimate is available, complete sequence is 2300-2500 nucleotides long. Segment 3 is sequenced, but only an estimate is given, complete sequence is 2200-2300 nucleotides long. Segment 4 has been fully sequenced, complete sequence is 1700-1800 nucleotides long. Segment 5 has been sequenced, but only an estimate is presented, complete sequence is 300-1900 nucleotides long. Segment 6 has been sequenced, but only an estimate is given, complete sequence is 1400-1500 nucleotides long. Segment 7 has been sequenced, but only an estimate is presented, complete sequence is 1000-1100 nucleotides long, has been sequenced, but only an estimate is available; complete sequence is 800-1100 nucleotides long. The genome has terminally redundant sequences. The genome sequence is repeated at both ends. Nucleotide sequences at the 3'-terminus are identical. The 5'-terminal sequence has conserved regions and repeats complementary to the 3'-terminus; terminal repeats at the 5'-end are 11-14 nucleotides long. The 3'-terminus has conserved nucleotide sequences; of 11-13 nucleotides in length; in genera of same family; sequence has conserved regions; in all RNA species, or some RNA segments. The multipartite genome is encapsidated, each segment in a separate nucleocapsid, and the nucleocapsids are surrounded by one envelope. Each virion contains defective interfering copies (may be present). Proteins The viral genome encodes structural proteins and non-structural proteins. Lipids Lipids are present and located in the envelope. Virions are composed of 18-37% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are modified cellular lipids and are derived from plasma membranes. Proteins of host derived membranes have been modified during post-translational processes. Host-derived membranes contain viral proteins in place of host proteins.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA16888
authentication:
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authorization:
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abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject