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Title: Humanized PRDM9 Mouse Testis H3K4me3 and DMC1 ChIP-seq      
keywords:
Other
ID:
PRJNA298164
description:
We report testis H3K4me3 and DMC1 enrichment at DSB hotspots in various mice to examine differences between infertile hybrid mice and mice that have been humanized at PRDM9, which have rescued fertility. We find that infertile mice have an excess of "asymmetric" DSB hotspots, where both H3K4me3 and DMC1 reads tend to originate from only one homologue. At these hotspots, we see an excess of DMC1 relative to H3K4me3, consistent with delayed DSB repair at these sites. See Davies et al. Nature 2016 for a complete summary. Overall design: Examination of adult testis H3K4me3 and DMC1 enrichment in different mice. This Series contains a re-analysis of Sample GSM869781 submitted by another user. The dmc1hotspots_B6.PRDM9bb* processed data files are linked as supplementary files at the foot of this Series record.
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA298164
authentication:
none
authorization:
none
ID:
pmid:26840484
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • 090532/Z/09/Z/Wellcome Trust/United Kingdom

  • 095552/Wellcome Trust/United Kingdom

  • 098387/Z/12/Z/Wellcome Trust/United Kingdom

  • Intramural NIH HHS/United States

  • 095552/Z/11/Z/Wellcome Trust/United Kingdom

  • 090532/Wellcome Trust/United Kingdom

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