Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Homo sapiens : Study of Human Developmental Neurogenesis      
ID:
PRJNA295468
description:
"We sought to characterize cellular heterogeneity in the human cortical germinal zone at a molecular level during peak stages of cortical neurogenesis. We captured single cells without enrichment and generated sequencing libraries using the C1TM Single-Cell Auto Prep System (Fluidigm), the SMARTer Ultra Low RNA Kit (Clontech), and the Nextera XT DNA Sample Preparation Kit (Illumina). We performed unbiased clustering of the single cells and further examined transcriptional variation among cell groups interpreted as radial glia. Within this population, the major sources of variation related to cell cycle progression and the stem cell niche from which radial glia were captured. We found that outer subventricular zone radial glia (oRG cells) preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR and related this transcriptional state to the position, morphology, and cell... (for more see dbGaP study page.)"
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA295468
authentication:
none
authorization:
none
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject