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Title: Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia      
keywords:
Variation
ID:
PRJNA255201
description:
T-ALL cell lines versus Bl57/6J spleen We investigated how RTK signaling might contribute to T-ALL using an established bone marrow transplantation model. To mimick tyrosine kinase signalling we expressed a constitutively active form of the TRKA receptor tyrosine kinase (ΔTrkA) in hematopoietic progenitor cells. Mice transplanted with ΔTrkA transduced cells developed T-ALL with a high penetrance. Overall design: comparative hybridization of DNA from T-ALL clones versus reference DNA (spleen)
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA255201
authentication:
none
authorization:
none
ID:
pmid:25241901
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject