biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia
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| keywords: |
Variation
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| ID: |
PRJNA255201
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| description: |
T-ALL cell lines versus Bl57/6J spleen
We investigated how RTK signaling might contribute to T-ALL using an established bone marrow transplantation model. To mimick tyrosine kinase signalling we expressed a constitutively active form of the TRKA receptor tyrosine kinase (ΔTrkA) in hematopoietic progenitor cells. Mice transplanted with ΔTrkA transduced cells developed T-ALL with a high penetrance.
Overall design: comparative hybridization of DNA from T-ALL clones versus reference DNA (spleen)
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| accesstypes: |
download
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| landingpage: | http://www.ncbi.nlm.nih.gov/bioproject/PRJNA255201 |
| authentication: |
none
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| authorization: |
none
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| ID: |
pmid:25241901
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| name: |
Mus musculus
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| ncbiID: |
ncbitax:10090
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| abbreviation: |
NCBI
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| homePage: | http://www.ncbi.nlm.nih.gov |
| ID: |
SCR:006472
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| name: |
National Center for Biotechnology Information
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| homePage: | http://www.ncbi.nlm.nih.gov/bioproject |
| ID: |
SCR:004801
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| name: |
NCBI BioProject
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