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Title: Genome-wide identification of Bcl11b gene targets      
keywords:
Transcriptome or Gene expression
ID:
PRJNA144713
description:
B-cell leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant expression in the striatum. To date, there are no known gene targets of Bcl11b in the nervous system. Here, we define targets for Bcl11b in striatal cells by performing genome-wide expression profiling. Transcriptome-wide analysis revealed that 694 genes were significantly altered in striatal cells over-expressing Bcl11b, including genes showing striatal-enriched expression similar to Bcl11b. Functional analysis on the gene target list identified significant association of Bcl11b to brain-derived neurotrophic factor/neurotrophin signaling. These data implicate Bcl11b as a novel regulator of the BDNF signaling pathway, which is disrupted in many neurological disorders. Overall design: n=4 wt STHdh striatal cells and n=4 Bcl11b-transfected STHdh striatal cells
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA144713
authentication:
none
authorization:
none
ID:
pmid:21912641
dateReleased:
08-02-2011
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject