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Title: Tumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer      
keywords:
Transcriptome or Gene expression
ID:
PRJNA126079
description:
BACKGROUND: The transcription factor c-Myb has been well characterized as an oncogene in several human tumor types, and its expression in the hematopoietic stem/progenitor cell population is essential for proper hematopoiesis. However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly understood, despite its high expression in the majority of breast cancer cases (60-80%). METHODOLOGY/PRINCIPAL FINDINGS: We find that c-Myb high expression in human breast tumors correlates with the luminal/ER+ phenotype and a good prognosis. Stable RNAi knock-down of endogenous c-Myb in the MCF7 luminal breast tumor cell line increased tumorigenesis both in vitro and in vivo, suggesting a possible tumor suppressor role in luminal breast cancer. We created a mammary-derived c-Myb expression signature, comprised of both direct and indirect c-Myb target genes, and found it to be highly correlated with a published mature luminal mammary cell signature and least correlated with a mammary stem/progenitor lineage gene signature. CONCLUSIONS/SIGNIFICANCE: These data describe, for the first time, a possible tumor suppressor role for the c-Myb proto-oncogene in breast cancer that has implications for the understanding of luminal tumorigenesis and for guiding treatment. Overall design: refXsample
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA126079
authentication:
none
authorization:
none
ID:
pmid:20949095
dateReleased:
10-15-2010
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • P30 ES010126/ES/NIEHS NIH HHS/United States

  • P50-CA58223-09A1/CA/NCI NIH HHS/United States

  • R01 CA138255/CA/NCI NIH HHS/United States

  • P50 CA058223/CA/NCI NIH HHS/United States

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