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Title: Expression data from Trk-overexpressing NB cell line SY5Y      
keywords:
Transcriptome or Gene expression
ID:
PRJNA118261
description:
Neurotrophin receptors play a pivotal role in the biology and prognosis of neuroblastoma (NB). While expression of TrkA/NTRK1 confers a good prognosis to NB patients, expression of TrkB/NTRK2 is associated with unfavorable outcome. We have transfected the neurotrophin-receptor null cell line SY5Y with either full-length TrkA or TrkB and performed transcriptional profiling to analyse the effects of Trk-expression without activation and in a time course after activation. Overall design: SY5Y transfected with either full length TrkA- or TrkB cDNA or vector control were cultivated in the absence or presence of their ligands NGF and BDNF, respectively. At the indicated time points cells were harvested and analysed using Affymetrix U95Av2 chips.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA118261
authentication:
none
authorization:
none
dateReleased:
10-05-2009
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject