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Title: Drosophila melanogaster developmental timecourse: wild type, eve, ftz      
keywords:
Transcriptome or Gene expression
ID:
PRJNA112513
description:
Transcriptional profiling of developmentally staged D. mel. Embryos for three genotypes: wild type, eve3 and ftz11 For additional information, please see Liu et al., 2009. Abstract: We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription factors involved in the process of embryonic segmentation. Analysis of the model allowed the identification of a new role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of the Jun-kinase phosphatase Puckered thereby inducing TNF/Eiger dependent apoptosis. In humans we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinoma (RCC), the most prevalent form of kidney cancer. SPOP expression distinguished histological subtypes of RCC and facilitated identification of clear cell RCC as the primary tumor for metastatic lesions. Keywords: 2 channel transcription timecourse Overall design: Developmental timecourse, 3 genotypes, experimental sample vs. common reference.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA112513
authentication:
none
authorization:
none
ID:
pmid:19164706
dateReleased:
12-31-2008
name:
Drosophila melanogaster
ncbiID:
ncbitax:7227
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • P50 GM081892-01A1/GM/NIGMS NIH HHS/United States

  • P50 GM081892/GM/NIGMS NIH HHS/United States

  • UL1 RR024999/RR/NCRR NIH HHS/United States

  • UL1 RR024999-02/RR/NCRR NIH HHS/United States

  • R01 HG003012-04/HG/NHGRI NIH HHS/United States

  • R01 HG003012/HG/NHGRI NIH HHS/United States

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