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Title: Comparison of SCG expression profiles from Bax null versus NGF-Bax double null mice      
keywords:
Transcriptome or Gene expression
ID:
PRJNA107953
description:
We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), which, through the receptor p75, can kill neighboring neurons with low retrograde NGF–TrkA signaling whereas neurons with high NGF–TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects. Keywords: comparative gene expression analysis Overall design: This experiment examine gene expression differences in superior cervical ganglia fro P0 bax null versus NGF-Bax double null animals. The Bax genotype was used in order to prevent the neuronal cell death normally observed in the NGF null animal.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA107953
authentication:
none
authorization:
none
ID:
pmid:18323418
dateReleased:
04-09-2008
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • F32 NS053187/NS/NINDS NIH HHS/United States

  • R01 NS034814/NS/NINDS NIH HHS/United States

  • R01 EY016281/EY/NEI NIH HHS/United States

  • Howard Hughes Medical Institute/United States

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