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Title: Coronaviridae      
ID:
PRJNA16880
description:
Description of Coronaviridae adapted from ICTVdb Virion Properties Morphology Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are spherical to pleomorphic, or kidney-shaped, or rod-shaped. Virions measure 120-160 nm in diameter, or 120-140 nm in diameter. Surface projections are spaced widely apart, evenly dispersed, distinctive, club-shaped peplomers that are surrounded by a prominent fringe and are comprised of S proteins responsible for attachment to cells, hemagglutination and membrane fusion and hemagglutinin esterase proteins (HE) which form short projections (in some species). Surface projections are composed of different types of proteins. Capsid/nucleocapsid is elongated and exhibits helical symmetry (or tubular). The nucleocapsid is helical, straight, or bent and a width of 9 nm, or 11-13 nm. Physicochemical and Physical Properties The molecular mass (Mr) of virions is 400 x 106. Virions have a buoyant density in CsCl of 1.23-1.24 g cm-3; sucrose of 1.15-1.19 g cm-3. The sedimentation coefficient is 300-500 S20w. Under in vitro conditions virions are some viruses stable in acid environment of pH 3. Virions are relatively stable in presence of Mg++ (heat inactivation of MHV reduced). Virions are sensitive to treatment with heat, lipid solvents, non-ionic detergents, formaldehyde, and oxidizing agents. Nucleic Acid The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 25000-33000 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap. The 3'-terminus has a poly (A) tract. Proteins The viral genome encodes structural proteins and non-structural proteins. Virions consist of 5 structural protein(s). Lipids Lipids are present and located in the envelope. Genome Organization and Replication By itself, genomic nucleic acid is infectious. Transcription: Sub-genomic RNA is present in infected cells. Translation: The genome replicates in the cytoplasm.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA16880
authentication:
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authorization:
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abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject