biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Coronaviridae
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| ID: |
PRJNA16880
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| description: |
Description of Coronaviridae
adapted from ICTVdb
Virion Properties
Morphology
Virions consist of an
envelope and a nucleocapsid. Virus capsid is enveloped. Virions
are spherical to pleomorphic, or kidney-shaped, or rod-shaped.
Virions measure 120-160 nm in diameter, or 120-140 nm in
diameter. Surface projections are spaced widely apart, evenly
dispersed, distinctive, club-shaped peplomers that are surrounded
by a prominent fringe and are comprised of S proteins responsible
for attachment to cells, hemagglutination and membrane fusion and
hemagglutinin esterase proteins (HE) which form short projections
(in some species). Surface projections are composed of different
types of proteins. Capsid/nucleocapsid is elongated and exhibits
helical symmetry (or tubular). The nucleocapsid is helical,
straight, or bent and a width of 9 nm, or 11-13 nm.
Physicochemical and Physical Properties
The molecular mass (Mr) of
virions is 400 x 106. Virions have a buoyant density
in CsCl of 1.23-1.24 g cm-3; sucrose of 1.15-1.19 g
cm-3. The sedimentation coefficient is 300-500
S20w. Under in vitro conditions virions
are some viruses stable in acid environment of pH 3. Virions are
relatively stable in presence of Mg++ (heat
inactivation of MHV reduced). Virions are sensitive to treatment
with heat, lipid solvents, non-ionic detergents, formaldehyde,
and oxidizing agents.
Nucleic Acid
The genome is not segmented and contains a single
molecule of linear positive-sense, single-stranded RNA. The
complete genome is 25000-33000 nucleotides long. The 5'-end of
the genome has a methylated nucleotide cap. The 3'-terminus has a
poly (A) tract.
Proteins
The viral genome encodes structural
proteins and non-structural proteins. Virions consist of 5
structural protein(s).
Lipids
Lipids are present and located in the
envelope.
Genome Organization and Replication
By itself, genomic nucleic acid is infectious.
Transcription:
Sub-genomic RNA is present in infected cells.
Translation: The genome
replicates in the cytoplasm.
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| accesstypes: |
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| landingpage: | http://www.ncbi.nlm.nih.gov/bioproject/PRJNA16880 |
| authentication: |
none
|
| authorization: |
none
|
| abbreviation: |
NCBI
|
| homePage: | http://www.ncbi.nlm.nih.gov |
| ID: |
SCR:006472
|
| name: |
National Center for Biotechnology Information
|
| homePage: | http://www.ncbi.nlm.nih.gov/bioproject |
| ID: |
SCR:004801
|
| name: |
NCBI BioProject
|