dateReleased: |
11-10-2011
|
description: |
Tissue-specific methylation patterns suggest a role for CpG island methylation in differentiation and cell-type-specific gene regulation. We have profiled CpG island methylation in different cells of the immune cell lineage to investigate this role. MBD-affinity purification combined with next generation sequencing was used to analyse CpG island methylation in dendritic cells, B cells, Th1, Th2 and naïve T cells. ChIP-seq was carried out to determine RNA polymerase II binding sites in these cell types and this was compared to the methylation profiles obtained. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see Abstract: We have profiled CpG island methylation in various immune system cell types and related this to gene expression in these cells.
|
privacy: |
not applicable
|
aggregation: |
instance of dataset
|
ID: |
E-ERAD-27
|
refinement: |
raw
|
keywords: |
functional genomics
|
dateModified: |
05-01-2014
|
creators: |
The Wellcome Trust Sanger Institute
|
availability: |
available
|
types: |
gene expression
|
name: |
Mus musculus
|
name: |
binding site identification design
|
accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.raw.1.zip![]() |
storedIn: |
ArrayExpress
|
qualifier: |
gzip compressed
|
format: |
TXT
|
accessType: |
download
|
authentication: |
none
|
authorization: |
none
|
accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.processed.1.zip![]() |
storedIn: |
ArrayExpress
|
qualifier: |
gzip compressed
|
format: |
TXT
|
accessType: |
download
|
authentication: |
none
|
authorization: |
none
|
abbreviation: |
EBI
|
homePage: | http://www.ebi.ac.uk/ |
ID: |
SCR:004727
|
name: |
European Bioinformatics Institute
|
homePage: | https://www.ebi.ac.uk/arrayexpress/ |
ID: |
SCR:002964
|
name: |
ArrayExpress
|
Transcription in Mecp2 null and Cfp1 null cells...
DNA sequence at CpG islands directly influences chromatin structure via the...
Chromatin and DNA methylation in human neuronal cells...
Comparison of transcriptional response of induced pluripotent stem iPS ce...
Transcriptome profiling protocol development...