biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | The role of CpG island methylation in immune cell gene regulation
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| dateReleased: |
11-10-2011
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| description: |
Tissue-specific methylation patterns suggest a role for CpG island methylation in differentiation and cell-type-specific gene regulation. We have profiled CpG island methylation in different cells of the immune cell lineage to investigate this role. MBD-affinity purification combined with next generation sequencing was used to analyse CpG island methylation in dendritic cells, B cells, Th1, Th2 and naïve T cells. ChIP-seq was carried out to determine RNA polymerase II binding sites in these cell types and this was compared to the methylation profiles obtained. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see Abstract: We have profiled CpG island methylation in various immune system cell types and related this to gene expression in these cells.
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| privacy: |
not applicable
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| aggregation: |
instance of dataset
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| ID: |
E-ERAD-27
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| refinement: |
raw
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| keywords: |
functional genomics
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| dateModified: |
05-01-2014
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| creators: |
The Wellcome Trust Sanger Institute
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| availability: |
available
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| types: |
gene expression
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| name: |
Mus musculus
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| name: |
binding site identification design
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| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.raw.1.zip |
| storedIn: |
ArrayExpress
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| qualifier: |
gzip compressed
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| format: |
TXT
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| accessType: |
download
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| authentication: |
none
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| authorization: |
none
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| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.processed.1.zip |
| storedIn: |
ArrayExpress
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| qualifier: |
gzip compressed
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| format: |
TXT
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| accessType: |
download
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| authentication: |
none
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| authorization: |
none
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| abbreviation: |
EBI
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| homePage: | http://www.ebi.ac.uk/ |
| ID: |
SCR:004727
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| name: |
European Bioinformatics Institute
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| homePage: | https://www.ebi.ac.uk/arrayexpress/ |
| ID: |
SCR:002964
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| name: |
ArrayExpress
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