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Title: Transcription profiling by array of zebrafish larvae treated with Para-Thyroid Hormone (PTH) against untreated controls      
dateReleased:
02-27-2015
description:
The general objective of the study was to determine modulation of gene expression by environmental factors, with a special emphasis on bone formation. For this reason, the specific period of treatment was chosen between 5-6 days post-fertilization (dpf), when bone formation and calcification are taking place. We show that treatment with Para-Thyroid Hormone (PTH) causes a clear decrease of bone formation, as illustrated by cranial skeleton staining of the bone matrix by Alizarin Red, by morphometric analysis of the resulting images and by gene expression studies of selected genes. Thus, a whole genome micro-array experiment was conducted to identify genes that may be involved in the observed effect on bone formation.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-3285
refinement:
raw
keywords:
functional genomics
dateModified:
02-02-2015
creators:
Rasoul Nourizadeh
availability:
available
types:
gene expression
name:
Danio rerio
name:
compound treatment design
ID:
A-MEXP-1717
name:
Agilent D. rerio (Zebrafish) Oligo Microarray 4x44K 019161 v1 (266 cols x 170 rows)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3285/E-MTAB-3285.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3285/E-MTAB-3285.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress