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Title: A Long Noncoding RNA Acts as a Tumor Promoter in Hepatocellular Carcinoma      
dateReleased:
01-14-2017
description:
Many long noncoding RNAs are involved in cancer development and progression. Here, we utilized high-throughput microarray to compare the expression difference of transcriptome between the LINC01225 stable knockdown SMCC7721 cells and mock empty plasmid treated SMCC7721 cells; the LINC01225 stable knockdown MHCC97H cells and mock empty plasmid treated MHCC97H cells. These altered genes are involved in tumorigenesis through diverse mechanisms. The present study reveals that LINC01225 functions as a tumor promoter in Hepatocellular Carcinoma. LINC01225 stable knockdown cells were compared to mock empty plasmid treated cells. In addition expression of genes in untreated SMCC7721 cells was detected, we performed a comparison between mock empty plasmid treated SMCC7721 cells and untreated SMCC7721 cells to determine that no confounding factors were brought in. The Agilent human lncRNA+mRNA Array V4.0 were used to perform the analysis.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-3833
refinement:
raw
dateSubmitted:
01-14-2015
keywords:
functional genomics
dateModified:
08-20-2015
creators:
Xiaochen Wang
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-19615
name:
CBC lncRNA + mRNA microarray V4.0
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3833/E-MTAB-3833.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3833/E-MTAB-3833.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress