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Title: Transcription profiling of human PC3 prostate cells transfected with FGF-8b vs control vector      
dateReleased:
06-01-2009
description:
The aim of this study was to identify molecular targets for FGF-8 associated with prostate cancer progression in PC3 prostate cancer cells. PC3 prostate cancer cells were stably transfected with FGF-8b or control vector (mock). Expression of FGF-8 in PC3 cells increased cell growth and MMP-production in vitro. Microarray analyses revealed 169 significantly altered genes (>2.0-fold), some of the which were known to be associated with cancer growth and may represent novel markers of FGF-8 function. Upregulated genes included those involved in angiogenesis or cell growth (DDAH2, CRIP1 and SHC). Genes associated with differentiation or cell death were downregulated (VDR, CYCS). This study demonstrates associated patterns of gene expressions for FGF-8 in prostate cancer. This analysis may help find new prognostic factors or therapeutic targets for prostate cancer.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MEXP-581
refinement:
raw
keywords:
functional genomics
dateModified:
05-02-2014
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-AGIL-9
name:
Agilent Human 1A Microarray (V2) 012097 G4110B
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MEXP-581/E-MEXP-581.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MEXP-581/E-MEXP-581.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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