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Title: Pain microarray analysis 2  
description:
Neonatal noxious insult produces a long-term effect on pain processing in adults. Rats subjected to carrageenan (CAR) injection in one hindpaw within the sensitive period develop bilateral hypoalgesia as adults. In the same rats, inflammation of the hindpaw, which was the site of the neonatal injury, induces a localized enhanced hyperalgesia limited to this paw. This study revealed significant basal and inflammation-associated aberrations in the expression of multiple genes in the LDH of adult animals receiving CAR injection at P3 as compared to their expression levels in the LDH of animals receiving either no injections or CAR injection at P12. In particular, at baseline, twelve genes (representing GABA, serotonin, adenosine, neuropeptide Y, cholecystokinin, opioid, tachykinin and interleukin systems) were up-regulated in the bilateral LDH of the former animals. The baseline condition in these animals was also characterized by up-regulation of seven genes (encoding members of GABA, cholecystokinin, histamine, serotonin, and neurotensin systems) in the LDH ipsilateral to the neonatally-injured paw. The largest aberration in gene expression, however, was observed during inflammation of the neonatally injured hindpaws in the ipsilateral LDH, which included thirty-six genes (encoding numerous members of glutamate, serotonin, GABA, calcitonin gene-related peptide, neurotrophin, and interleukin systems). These findings suggest that changes in gene expression may be involved in the long-term nociceptive effects of neonatal noxious insult at the spinal level. Last Updated (by provider): Mar 20 2007 Contributers: Michael S Lidow Fang He Jie Bai Svetlana I Novikova
privacy:
not applicable
aggregation:
instance of dataset
ID:
1638
refinement:
curated
keywords:
functional genomics
availability:
available
types:
gene expression
ID:
GEO:GSE7328
accessURL: http://www.chibi.ubc.ca/Gemma/expressionExperiment/showExpressionExperiment.html?id=1638
storedIn:
Gemma
qualifier:
filtered
format:
TSV
accessType:
Submit Job
authentication:
none
authorization:
none
accessURL: http://www.chibi.ubc.ca/Gemma/expressionExperiment/showExpressionExperiment.html?id=1638
storedIn:
Gemma
qualifier:
unfiltered
format:
TSV
accessType:
Submit Job
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE7328
storedIn:
Gene Expression Omnibus
format:
HTML
accessType:
Landing Page
primary:
true
authentication:
none
authorization:
none
abbreviation:
UBC
homePage: http://www.ubc.ca/
ID:
SCR:011614
name:
University of British Columbia
homePage: http://www.chibi.ubc.ca/Gemma
ID:
SCR:008007
name:
Gemma