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Title: Structure of AMPK bound to activator      
dateReleased:
05-17-2017
creators:
Cokorinos, E.C.
Delmore, J.
Reyes, A.R.
Albuquerque, B.
Kjbsted, R.
Jrgensen, N.O.
Tran, J.L.
Jatkar, A.
Cialdea, K.
Esquejo, R.M.
Meissen, J.
Calabrese, M.F.
Cordes, J.
Moccia, R.
Tess, D.
Salatto, C.T.
Coskran, T.M.
Opsahl, A.C.
Flynn, D.
Blatnik, M.
Li, W.
Kindt, E.
Foretz, M.
Viollet, B.
Ward, J.
Kurumbail, R.G.
Kalgutkar, A.S.
Wojtaszewski, J.F.P.
Cameron, K.O.
Miller, R.A.
description:
5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1,2.7.11.1,2.7.11.27,2.7.11.31,2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1
privacy:
not applicable
aggregation:
instance of dataset
ID:
PDB:5UFU
refinement:
curated
keywords:
TRANSFERASE/ACTIVATOR
Kinase
AMPK
activator
allostery
TRANSFERASE-ACTIVATOR complex
dateCreated:
01-05-2017
availability:
available
types:
structure
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Mus musculus
ID:
ncbitax:10090
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Escherichia coli
ID:
ncbitax:562
name:
Escherichia coli
ID:
ncbitax:562
name:
Escherichia coli
ID:
ncbitax:562
name:
Escherichia coli
ID:
ncbitax:562
authors:
Cokorinos, E.C.
Delmore, J.
Reyes, A.R.
Albuquerque, B.
Kjbsted, R.
Jrgensen, N.O.
Tran, J.L.
Jatkar, A.
Cialdea, K.
Esquejo, R.M.
Meissen, J.
Calabrese, M.F.
Cordes, J.
Moccia, R.
Tess, D.
Salatto, C.T.
Coskran, T.M.
Opsahl, A.C.
Flynn, D.
Blatnik, M.
Li, W.
Kindt, E.
Foretz, M.
Viollet, B.
Ward, J.
Kurumbail, R.G.
Kalgutkar, A.S.
Wojtaszewski, J.F.P.
Cameron, K.O.
Miller, R.A.
alternateID:
doi:10.1016/j.cmet.2017.04.010
year:
2017
ID: pmid:28467931
title:
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
formula:
C23 H23 Cl N2 O5
name:
1,4:3,6-dianhydro-2-O-(6-chloro-5-{4-[1-(hydroxymethyl)cyclopropyl]phenyl}-1H-benzimidazol-2-yl)-D-mannitol
roles:
chemical component
formula:
C10 H15 N5 O10 P2
name:
ADENOSINE-5'-DIPHOSPHATE
roles:
chemical component
formula:
C3 H7 N O2
name:
ALANINE
roles:
chemical component
formula:
C10 H14 N5 O7 P
name:
ADENOSINE MONOPHOSPHATE
roles:
chemical component
formula:
C6 H15 N4 O2 1
name:
ARGININE
roles:
chemical component
formula:
C4 H8 N2 O3
name:
ASPARAGINE
roles:
chemical component
formula:
C4 H7 N O4
name:
ASPARTIC ACID
roles:
chemical component
formula:
Cl -1
name:
CHLORIDE ION
roles:
chemical component
formula:
C3 H7 N O2 S
name:
CYSTEINE
roles:
chemical component
formula:
C5 H10 N2 O3
name:
GLUTAMINE
roles:
chemical component
formula:
C5 H9 N O4
name:
GLUTAMIC ACID
roles:
chemical component
formula:
C2 H5 N O2
name:
GLYCINE
roles:
chemical component
formula:
C6 H10 N3 O2 1
name:
HISTIDINE
roles:
chemical component
formula:
C6 H13 N O2
name:
ISOLEUCINE
roles:
chemical component
formula:
C6 H13 N O2
name:
LEUCINE
roles:
chemical component
formula:
C6 H15 N2 O2 1
name:
LYSINE
roles:
chemical component
formula:
C5 H11 N O2 S
name:
METHIONINE
roles:
chemical component
formula:
C9 H11 N O2
name:
PHENYLALANINE
roles:
chemical component
formula:
C5 H9 N O2
name:
PROLINE
roles:
chemical component
formula:
C3 H7 N O3
name:
SERINE
roles:
chemical component
formula:
O4 S -2
name:
SULFATE ION
roles:
chemical component
formula:
C28 H26 N4 O3
name:
STAUROSPORINE
roles:
chemical component
formula:
C4 H9 N O3
name:
THREONINE
roles:
chemical component
formula:
C4 H10 N O6 P
name:
PHOSPHOTHREONINE
roles:
chemical component
formula:
C11 H12 N2 O2
name:
TRYPTOPHAN
roles:
chemical component
formula:
C9 H11 N O3
name:
TYROSINE
roles:
chemical component
formula:
C5 H11 N O2
name:
VALINE
roles:
chemical component
name:
Prkaa1, Ampk1
name:
Prkaa1
name:
Prkab1
name:
Prkag1
name:
X-RAY DIFFRACTION
ID:
pdb:5UFU
ID:
wwpdb:D_1000225795
accessURL: https://files.rcsb.org/download/5UFU.xml.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBML/XML
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5UFU.pdb.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5UFU.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBx/mmCIF
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=5UFU
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
FASTA
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5UFU-sf.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
CIF
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5UFU.pdb1.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format (A)
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=5UFU&bionumber=1
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
JSmol
accessType:
view
authentication:
none
authorization:
none
abbreviation:
wwPDB
homePage: http://www.wwpdb.org
ID:
SCR:006555
name:
Worldwide Protein Data Bank
abbreviation:
PDB
homePage: http://www.rcsb.org/pdb/
ID:
SCR:012820
name:
Protein Data Bank