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Title: CRYSTAL STRUCTURE OF AN AUTOIMMUNE COMPLEX BETWEEN A HUMAN IGM RHEUMATOID FACTOR AND IGG1 FC REVEALS A NOVEL FC EPITOPE AND EVIDENCE FOR AFFINITY MATURATION      
description:
IG GAMMA-1 CHAIN C REGION, IGM
privacy:
not applicable
aggregation:
instance of dataset
ID:
PDB:2J6E
refinement:
curated
keywords:
IMMUNE SYSTEM
AUTOIMMUNE COMPLEX HUMAN IGM RHEUMATOID FACTOR IGG1-FC
IMMUNOGLOBULIN C REGION
MEMBRANE
GLYCOPROTEIN
TRANSMEMBRANE
HYPOTHETICAL PROTEIN
IMMUNOGLOBULIN DOMAIN
creators:
Duquerroy, S.
Stura, E.A.
Bressanelli, S.
Fabiane, S.M.
Vaney, M.-C.
Beale, D.
Hamon, M.
Casali, P.
Rey, F.A.
Sutton, B.J.
Taussig, M.J.
availability:
available
types:
structure
name:
HOMO SAPIENS
ID:
ncbitax:9606
name:
HOMO SAPIENS
ID:
ncbitax:9606
name:
HOMO SAPIENS
ID:
ncbitax:9606
name:
CRICETULUS GRISEUS
ID:
ncbitax:10029
name:
HOMO SAPIENS
ID:
ncbitax:9606
name:
HOMO SAPIENS
ID:
ncbitax:9606
authors:
Duquerroy, S.
Stura, E.A.
Bressanelli, S.
Fabiane, S.M.
Vaney, M.-C.
Beale, D.
Hamon, M.
Casali, P.
Rey, F.A.
Sutton, B.J.
Taussig, M.J.
alternateID:
doi:10.1016/j.jmb.2007.02.085
year:
2007
ID: pmid:17395205
title:
Crystal Structure of a Human Autoimmune Complex between Igm Rheumatoid Factor Rf61 and Igg1 Fc Reveals a Novel Epitope and Evidence for Affinity Maturation.
formula:
C2 H5 N O2
name:
GLYCINE
roles:
chemical component
formula:
C5 H9 N O2
name:
PROLINE
roles:
chemical component
formula:
C3 H7 N O3
name:
SERINE
roles:
chemical component
formula:
C5 H11 N O2
name:
VALINE
roles:
chemical component
formula:
C9 H11 N O2
name:
PHENYLALANINE
roles:
chemical component
formula:
C6 H13 N O2
name:
LEUCINE
roles:
chemical component
formula:
C6 H15 N2 O2 1
name:
LYSINE
roles:
chemical component
formula:
C4 H7 N O4
name:
ASPARTIC ACID
roles:
chemical component
formula:
C4 H9 N O3
name:
THREONINE
roles:
chemical component
formula:
C5 H11 N O2 S
name:
METHIONINE
roles:
chemical component
formula:
C6 H13 N O2
name:
ISOLEUCINE
roles:
chemical component
formula:
C6 H15 N4 O2 1
name:
ARGININE
roles:
chemical component
formula:
C5 H9 N O4
name:
GLUTAMIC ACID
roles:
chemical component
formula:
C3 H7 N O2 S
name:
CYSTEINE
roles:
chemical component
formula:
C6 H10 N3 O2 1
name:
HISTIDINE
roles:
chemical component
formula:
C4 H8 N2 O3
name:
ASPARAGINE
roles:
chemical component
formula:
C11 H12 N2 O2
name:
TRYPTOPHAN
roles:
chemical component
formula:
C9 H11 N O3
name:
TYROSINE
roles:
chemical component
formula:
C3 H7 N O2
name:
ALANINE
roles:
chemical component
formula:
C5 H10 N2 O3
name:
GLUTAMINE
roles:
chemical component
formula:
CD 2
name:
CADMIUM ION
roles:
chemical component
formula:
ZN 2
name:
ZINC ION
roles:
chemical component
formula:
C2 H6 AS O2 -1
name:
CACODYLATE ION
roles:
chemical component
formula:
C6 H14 O2
name:
(4S)-2-METHYL-2,4-PENTANEDIOL
roles:
chemical component
formula:
C2 H3 O2 -1
name:
ACETATE ION
roles:
chemical component
formula:
C8 H15 N O6
name:
N-ACETYL-D-GLUCOSAMINE
roles:
chemical component
formula:
C6 H12 O5
name:
BETA-L-FUCOSE
roles:
chemical component
formula:
C6 H12 O6
name:
BETA-D-MANNOSE
roles:
chemical component
formula:
C6 H12 O6
name:
ALPHA-D-MANNOSE
roles:
chemical component
formula:
C8 H15 N O6
name:
2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE
roles:
chemical component
formula:
C6 H12 O6
name:
BETA-D-GALACTOSE
roles:
chemical component
formula:
H2 O
name:
WATER
roles:
chemical component
name:
X-RAY DIFFRACTION
ID:
pdb:2J6E
ID:
pdbe:EBI-30026
accessURL: https://files.rcsb.org/download/2J6E.xml.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBML/XML
accessType:
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authentication:
none
authorization:
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accessURL: https://files.rcsb.org/download/2J6E.pdb.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/2J6E.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBx/mmCIF
accessType:
download
authentication:
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authorization:
none
accessURL: http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=2J6E
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
FASTA
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/2J6E-sf.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
CIF
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/2J6E.pdb1.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format (A)
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=2J6E&bionumber=1
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
JSmol
accessType:
view
authentication:
none
authorization:
none
abbreviation:
wwPDB
homePage: http://www.wwpdb.org
ID:
SCR:006555
name:
Worldwide Protein Data Bank
abbreviation:
PDB
homePage: http://www.rcsb.org/pdb/
ID:
SCR:012820
name:
Protein Data Bank