biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
|
| description: |
HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
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| privacy: |
not applicable
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| aggregation: |
instance of dataset
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| ID: |
PDB:4H6J
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| refinement: |
curated
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| keywords: |
TRANSCRIPTION
PAS DOMAIN
HETERODIMER
HYPOXIA INDUCIBLE FACTOR
TRANSCRIPTION FACTOR
ARNT
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| creators: |
Cardoso, R.
Love, R.
Nilsson, C.L.
Bergqvist, S.
Nowlin, D.
Yan, J.
Liu, K.K.
Zhu, J.
Chen, P.
Deng, Y.L.
Dyson, H.J.
Greig, M.J.
Brooun, A.
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| availability: |
available
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| types: |
structure
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| strain: |
BL21 (AI)
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| name: |
Homo sapiens
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| ID: |
ncbitax:9606
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| strain: |
BL21 (AI)
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| name: |
Homo sapiens
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| ID: |
ncbitax:9606
|
| name: |
Escherichia coli
|
| ID: |
ncbitax:511693
|
| name: |
Escherichia coli
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| ID: |
ncbitax:511693
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| authors: |
Cardoso, R.
Love, R.
Nilsson, C.L.
Bergqvist, S.
Nowlin, D.
Yan, J.
Liu, K.K.
Zhu, J.
Chen, P.
Deng, Y.L.
Dyson, H.J.
Greig, M.J.
Brooun, A.
|
| alternateID: |
doi:10.1002/pro.2172
|
| year: |
2012
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| ID: | pmid:23033253 |
| title: |
Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
|
| formula: |
C4 H7 N O4
|
| name: |
ASPARTIC ACID
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O3
|
| name: |
SERINE
|
| roles: |
chemical component
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| formula: |
C6 H15 N2 O2 1
|
| name: |
LYSINE
|
| roles: |
chemical component
|
| formula: |
C4 H9 N O3
|
| name: |
THREONINE
|
| roles: |
chemical component
|
| formula: |
C9 H11 N O2
|
| name: |
PHENYLALANINE
|
| roles: |
chemical component
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| formula: |
C6 H13 N O2
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| name: |
LEUCINE
|
| roles: |
chemical component
|
| formula: |
C5 H9 N O4
|
| name: |
GLUTAMIC ACID
|
| roles: |
chemical component
|
| formula: |
C6 H10 N3 O2 1
|
| name: |
HISTIDINE
|
| roles: |
chemical component
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| formula: |
C5 H11 N O2 S
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| name: |
METHIONINE
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| roles: |
chemical component
|
| formula: |
C9 H11 N O3
|
| name: |
TYROSINE
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O2 S
|
| name: |
CYSTEINE
|
| roles: |
chemical component
|
| formula: |
C6 H15 N4 O2 1
|
| name: |
ARGININE
|
| roles: |
chemical component
|
| formula: |
C6 H13 N O2
|
| name: |
ISOLEUCINE
|
| roles: |
chemical component
|
| formula: |
C2 H5 N O2
|
| name: |
GLYCINE
|
| roles: |
chemical component
|
| formula: |
C5 H9 N O2
|
| name: |
PROLINE
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O2
|
| name: |
ALANINE
|
| roles: |
chemical component
|
| formula: |
C5 H10 N2 O3
|
| name: |
GLUTAMINE
|
| roles: |
chemical component
|
| formula: |
C5 H11 N O2
|
| name: |
VALINE
|
| roles: |
chemical component
|
| formula: |
C11 H12 N2 O2
|
| name: |
TRYPTOPHAN
|
| roles: |
chemical component
|
| formula: |
C4 H8 N2 O3
|
| name: |
ASPARAGINE
|
| roles: |
chemical component
|
| formula: |
H2 O
|
| name: |
WATER
|
| roles: |
chemical component
|
| name: |
HIF-1 alpha
|
| name: |
ARNT
|
| name: |
X-RAY DIFFRACTION
|
| ID: |
pdb:4H6J
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| ID: |
rcsb:RCSB075081
|
| accessURL: | https://files.rcsb.org/download/4H6J.xml.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDBML/XML
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4H6J.pdb.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDB Format
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4H6J.cif.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDBx/mmCIF
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=4H6J |
| storedIn: |
Protein Data Bank
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
FASTA
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4H6J-sf.cif.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
CIF
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4H6J.pdb1.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDB Format (A)
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | http://www.rcsb.org/pdb/explore/jmol.do?structureId=4H6J&bionumber=1 |
| storedIn: |
Protein Data Bank
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
JSmol
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| accessType: |
view
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| authentication: |
none
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| authorization: |
none
|
| abbreviation: |
wwPDB
|
| homePage: | http://www.wwpdb.org |
| ID: |
SCR:006555
|
| name: |
Worldwide Protein Data Bank
|
| abbreviation: |
PDB
|
| homePage: | http://www.rcsb.org/pdb/ |
| ID: |
SCR:012820
|
| name: |
Protein Data Bank
|