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Title: Crystal structure of antibody VRC07-G54Y in complex with clade A/E 93TH057 HIV-1 gp120 core      
description:
Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01
privacy:
not applicable
aggregation:
instance of dataset
ID:
PDB:4OM0
refinement:
curated
keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
VRC07 antibody
Passive transfer
Neutralization
In vivo protection
Autoreactivity
Lentiviral infection
Enhanced potency
HIV-1 gp120
VRC07-G54Y
VIRAL PROTEIN-IMMUNE SYSTEM complex
creators:
Rudicell, R.S.
Kwon, Y.D.
Ko, S.Y.
Pegu, A.
Louder, M.K.
Georgiev, I.S.
Wu, X.
Zhu, J.
Boyington, J.C.
Chen, X.
Shi, W.
Yang, Z.Y.
Doria-Rose, N.A.
McKee, K.
O'Dell, S.
Schmidt, S.D.
Chuang, G.Y.
Druz, A.
Soto, C.
Yang, Y.
Zhang, B.
Zhou, T.
Todd, J.P.
Lloyd, K.E.
Eudailey, J.
Roberts, K.E.
Donald, B.R.
Bailer, R.T.
Ledgerwood, J.
Mullikin, J.C.
Shapiro, L.
Koup, R.A.
Graham, B.S.
Nason, M.C.
Connors, M.
Haynes, B.F.
Rao, S.S.
Roederer, M.
Kwong, P.D.
Mascola, J.R.
Nabel, G.J.
availability:
available
types:
structure
strain:
93TH057
name:
Human immunodeficiency virus 1
ID:
ncbitax:11676
strain:
293F cells
name:
Homo sapiens
ID:
ncbitax:9606
strain:
293F cells
name:
Homo sapiens
ID:
ncbitax:9606
strain:
293F cells
name:
Homo sapiens
ID:
ncbitax:9606
name:
Homo sapiens
ID:
ncbitax:9606
name:
Homo sapiens
ID:
ncbitax:9606
authors:
Rudicell, R.S.
Kwon, Y.D.
Ko, S.Y.
Pegu, A.
Louder, M.K.
Georgiev, I.S.
Wu, X.
Zhu, J.
Boyington, J.C.
Chen, X.
Shi, W.
Yang, Z.Y.
Doria-Rose, N.A.
McKee, K.
O'Dell, S.
Schmidt, S.D.
Chuang, G.Y.
Druz, A.
Soto, C.
Yang, Y.
Zhang, B.
Zhou, T.
Todd, J.P.
Lloyd, K.E.
Eudailey, J.
Roberts, K.E.
Donald, B.R.
Bailer, R.T.
Ledgerwood, J.
Mullikin, J.C.
Shapiro, L.
Koup, R.A.
Graham, B.S.
Nason, M.C.
Connors, M.
Haynes, B.F.
Rao, S.S.
Roederer, M.
Kwong, P.D.
Mascola, J.R.
Nabel, G.J.
alternateID:
doi:10.1128/JVI.02213-14
year:
2014
ID: pmid:25142607
title:
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
formula:
C5 H11 N O2
name:
VALINE
roles:
chemical component
formula:
C11 H12 N2 O2
name:
TRYPTOPHAN
roles:
chemical component
formula:
C6 H15 N2 O2 1
name:
LYSINE
roles:
chemical component
formula:
C4 H7 N O4
name:
ASPARTIC ACID
roles:
chemical component
formula:
C3 H7 N O2
name:
ALANINE
roles:
chemical component
formula:
C4 H9 N O3
name:
THREONINE
roles:
chemical component
formula:
C6 H13 N O2
name:
LEUCINE
roles:
chemical component
formula:
C9 H11 N O2
name:
PHENYLALANINE
roles:
chemical component
formula:
C3 H7 N O2 S
name:
CYSTEINE
roles:
chemical component
formula:
C3 H7 N O3
name:
SERINE
roles:
chemical component
formula:
C6 H10 N3 O2 1
name:
HISTIDINE
roles:
chemical component
formula:
C5 H9 N O4
name:
GLUTAMIC ACID
roles:
chemical component
formula:
C4 H8 N2 O3
name:
ASPARAGINE
roles:
chemical component
formula:
C5 H9 N O2
name:
PROLINE
roles:
chemical component
formula:
C5 H10 N2 O3
name:
GLUTAMINE
roles:
chemical component
formula:
C6 H13 N O2
name:
ISOLEUCINE
roles:
chemical component
formula:
C5 H11 N O2 S
name:
METHIONINE
roles:
chemical component
formula:
C2 H5 N O2
name:
GLYCINE
roles:
chemical component
formula:
C9 H11 N O3
name:
TYROSINE
roles:
chemical component
formula:
C6 H15 N4 O2 1
name:
ARGININE
roles:
chemical component
formula:
C8 H15 N O6
name:
N-ACETYL-D-GLUCOSAMINE
roles:
chemical component
formula:
H2 O
name:
WATER
roles:
chemical component
name:
Env, pol
name:
Heavy chain
name:
Light chain
name:
X-RAY DIFFRACTION
ID:
pdb:4OM0
ID:
rcsb:RCSB084661
accessURL: https://files.rcsb.org/download/4OM0.xml.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBML/XML
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4OM0.pdb.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4OM0.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBx/mmCIF
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=4OM0
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
FASTA
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4OM0-sf.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
CIF
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4OM0.pdb1.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format (A)
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=4OM0&bionumber=1
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
JSmol
accessType:
view
authentication:
none
authorization:
none
abbreviation:
wwPDB
homePage: http://www.wwpdb.org
ID:
SCR:006555
name:
Worldwide Protein Data Bank
abbreviation:
PDB
homePage: http://www.rcsb.org/pdb/
ID:
SCR:012820
name:
Protein Data Bank