biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Crystal structure of antibody VRC07-G54L in complex with clade A/E 93TH057 HIV-1 gp120 core
|
| description: |
Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01
|
| privacy: |
not applicable
|
| aggregation: |
instance of dataset
|
| ID: |
PDB:4OLX
|
| refinement: |
curated
|
| keywords: |
VIRAL PROTEIN/IMMUNE SYSTEM
VRC07 antibody
Passive transfer
Neutralization
In vivo protection
Autoreactivity
Lentiviral infection
Enhanced potency
HIV-1 gp120
VRC07-G54L
VIRAL PROTEIN-IMMUNE SYSTEM complex
|
| creators: |
Rudicell, R.S.
Kwon, Y.D.
Ko, S.Y.
Pegu, A.
Louder, M.K.
Georgiev, I.S.
Wu, X.
Zhu, J.
Boyington, J.C.
Chen, X.
Shi, W.
Yang, Z.Y.
Doria-Rose, N.A.
McKee, K.
O'Dell, S.
Schmidt, S.D.
Chuang, G.Y.
Druz, A.
Soto, C.
Yang, Y.
Zhang, B.
Zhou, T.
Todd, J.P.
Lloyd, K.E.
Eudailey, J.
Roberts, K.E.
Donald, B.R.
Bailer, R.T.
Ledgerwood, J.
Mullikin, J.C.
Shapiro, L.
Koup, R.A.
Graham, B.S.
Nason, M.C.
Connors, M.
Haynes, B.F.
Rao, S.S.
Roederer, M.
Kwong, P.D.
Mascola, J.R.
Nabel, G.J.
|
| availability: |
available
|
| types: |
structure
|
| strain: |
93TH057
|
| name: |
Human immunodeficiency virus 1
|
| ID: |
ncbitax:11676
|
| strain: |
293F cells
|
| name: |
Homo sapiens
|
| ID: |
ncbitax:9606
|
| strain: |
293F cells
|
| name: |
Homo sapiens
|
| ID: |
ncbitax:9606
|
| strain: |
293F cells
|
| name: |
Homo sapiens
|
| ID: |
ncbitax:9606
|
| name: |
Homo sapiens
|
| ID: |
ncbitax:9606
|
| name: |
Homo sapiens
|
| ID: |
ncbitax:9606
|
| authors: |
Rudicell, R.S.
Kwon, Y.D.
Ko, S.Y.
Pegu, A.
Louder, M.K.
Georgiev, I.S.
Wu, X.
Zhu, J.
Boyington, J.C.
Chen, X.
Shi, W.
Yang, Z.Y.
Doria-Rose, N.A.
McKee, K.
O'Dell, S.
Schmidt, S.D.
Chuang, G.Y.
Druz, A.
Soto, C.
Yang, Y.
Zhang, B.
Zhou, T.
Todd, J.P.
Lloyd, K.E.
Eudailey, J.
Roberts, K.E.
Donald, B.R.
Bailer, R.T.
Ledgerwood, J.
Mullikin, J.C.
Shapiro, L.
Koup, R.A.
Graham, B.S.
Nason, M.C.
Connors, M.
Haynes, B.F.
Rao, S.S.
Roederer, M.
Kwong, P.D.
Mascola, J.R.
Nabel, G.J.
|
| alternateID: |
doi:10.1128/JVI.02213-14
|
| year: |
2014
|
| ID: | pmid:25142607 |
| title: |
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
|
| formula: |
C5 H11 N O2
|
| name: |
VALINE
|
| roles: |
chemical component
|
| formula: |
C11 H12 N2 O2
|
| name: |
TRYPTOPHAN
|
| roles: |
chemical component
|
| formula: |
C6 H15 N2 O2 1
|
| name: |
LYSINE
|
| roles: |
chemical component
|
| formula: |
C4 H7 N O4
|
| name: |
ASPARTIC ACID
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O2
|
| name: |
ALANINE
|
| roles: |
chemical component
|
| formula: |
C4 H9 N O3
|
| name: |
THREONINE
|
| roles: |
chemical component
|
| formula: |
C6 H13 N O2
|
| name: |
LEUCINE
|
| roles: |
chemical component
|
| formula: |
C9 H11 N O2
|
| name: |
PHENYLALANINE
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O2 S
|
| name: |
CYSTEINE
|
| roles: |
chemical component
|
| formula: |
C3 H7 N O3
|
| name: |
SERINE
|
| roles: |
chemical component
|
| formula: |
C6 H10 N3 O2 1
|
| name: |
HISTIDINE
|
| roles: |
chemical component
|
| formula: |
C5 H9 N O4
|
| name: |
GLUTAMIC ACID
|
| roles: |
chemical component
|
| formula: |
C4 H8 N2 O3
|
| name: |
ASPARAGINE
|
| roles: |
chemical component
|
| formula: |
C5 H9 N O2
|
| name: |
PROLINE
|
| roles: |
chemical component
|
| formula: |
C5 H10 N2 O3
|
| name: |
GLUTAMINE
|
| roles: |
chemical component
|
| formula: |
C6 H13 N O2
|
| name: |
ISOLEUCINE
|
| roles: |
chemical component
|
| formula: |
C5 H11 N O2 S
|
| name: |
METHIONINE
|
| roles: |
chemical component
|
| formula: |
C2 H5 N O2
|
| name: |
GLYCINE
|
| roles: |
chemical component
|
| formula: |
C9 H11 N O3
|
| name: |
TYROSINE
|
| roles: |
chemical component
|
| formula: |
C6 H15 N4 O2 1
|
| name: |
ARGININE
|
| roles: |
chemical component
|
| formula: |
C8 H15 N O6
|
| name: |
N-ACETYL-D-GLUCOSAMINE
|
| roles: |
chemical component
|
| formula: |
H2 O
|
| name: |
WATER
|
| roles: |
chemical component
|
| name: |
Env, pol
|
| name: |
Heavy chain
|
| name: |
Light chain
|
| name: |
X-RAY DIFFRACTION
|
| ID: |
pdb:4OLX
|
| ID: |
rcsb:RCSB084658
|
| accessURL: | https://files.rcsb.org/download/4OLX.xml.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDBML/XML
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4OLX.pdb.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDB Format
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4OLX.cif.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDBx/mmCIF
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=4OLX |
| storedIn: |
Protein Data Bank
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
FASTA
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4OLX-sf.cif.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
CIF
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://files.rcsb.org/download/4OLX.pdb1.gz |
| storedIn: |
Protein Data Bank
|
| qualifier: |
gzip compressed
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
PDB Format (A)
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | http://www.rcsb.org/pdb/explore/jmol.do?structureId=4OLX&bionumber=1 |
| storedIn: |
Protein Data Bank
|
| license: |
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
|
| format: |
JSmol
|
| accessType: |
view
|
| authentication: |
none
|
| authorization: |
none
|
| abbreviation: |
wwPDB
|
| homePage: | http://www.wwpdb.org |
| ID: |
SCR:006555
|
| name: |
Worldwide Protein Data Bank
|
| abbreviation: |
PDB
|
| homePage: | http://www.rcsb.org/pdb/ |
| ID: |
SCR:012820
|
| name: |
Protein Data Bank
|
Crystal structure of antibody VRC07-G54F in complex with clade A/E 93TH057 ...
Crystal structure of antibody VRC07-G54R in complex with clade A/E 93TH057 ...
Crystal structure of antibody VRC07 in complex with clade A/E 93TH057 HIV-1...
Crystal structure of antibody VRC07-G54W in complex with clade A/E 93TH057 ...
Crystal structure of antibody VRC07-G54H in complex with clade A/E 93TH057 ...
Crystal structure of antibody VRC07-G54Y in complex with clade A/E 93TH057 ...