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Title: AMPK bound to allosteric activator      
description:
5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1,2.7.11.27,2.7.11.31,2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1
privacy:
not applicable
aggregation:
instance of dataset
ID:
PDB:5T5T
refinement:
curated
keywords:
TRANSFERASE
AMPK
Kinase
allostery
activator
creators:
Salatto, C.T.
Miller, R.A.
Cameron, K.O.
Cokorinos, E.
Reyes, A.
Ward, J.
Calabrese, M.F.
Kurumbail, R.G.
Rajamohan, F.
Kalgutkar, A.S.
Tess, D.A.
Shavnya, A.
Genung, N.E.
Edmonds, D.J.
Jatkar, A.
Maciejewski, B.S.
Amaro, M.
Gandhok, H.
Monetti, M.
Cialdea, K.
Bollinger, E.
Kreeger, J.M.
Coskran, T.M.
Opsahl, A.C.
Boucher, G.G.
Birnbaum, M.J.
DaSilva-Jardine, P.
Rolph, T.
availability:
available
types:
structure
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Rattus norvegicus
ID:
ncbitax:10116
name:
Escherichia coli
ID:
ncbitax:562
name:
Escherichia coli
ID:
ncbitax:562
name:
Escherichia coli
ID:
ncbitax:562
authors:
Salatto, C.T.
Miller, R.A.
Cameron, K.O.
Cokorinos, E.
Reyes, A.
Ward, J.
Calabrese, M.F.
Kurumbail, R.G.
Rajamohan, F.
Kalgutkar, A.S.
Tess, D.A.
Shavnya, A.
Genung, N.E.
Edmonds, D.J.
Jatkar, A.
Maciejewski, B.S.
Amaro, M.
Gandhok, H.
Monetti, M.
Cialdea, K.
Bollinger, E.
Kreeger, J.M.
Coskran, T.M.
Opsahl, A.C.
Boucher, G.G.
Birnbaum, M.J.
DaSilva-Jardine, P.
Rolph, T.
alternateID:
doi:10.1124/jpet.116.237925
year:
2017
ID: pmid:28289077
title:
Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
formula:
C17 H16 Cl N3 O3
name:
6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carboxylic acid
roles:
chemical component
formula:
C10 H15 N5 O10 P2
name:
ADENOSINE-5'-DIPHOSPHATE
roles:
chemical component
formula:
C3 H7 N O2
name:
ALANINE
roles:
chemical component
formula:
C10 H14 N5 O7 P
name:
ADENOSINE MONOPHOSPHATE
roles:
chemical component
formula:
C6 H15 N4 O2 1
name:
ARGININE
roles:
chemical component
formula:
C4 H8 N2 O3
name:
ASPARAGINE
roles:
chemical component
formula:
C4 H7 N O4
name:
ASPARTIC ACID
roles:
chemical component
formula:
Cl -1
name:
CHLORIDE ION
roles:
chemical component
formula:
C3 H7 N O2 S
name:
CYSTEINE
roles:
chemical component
formula:
C5 H10 N2 O3
name:
GLUTAMINE
roles:
chemical component
formula:
C5 H9 N O4
name:
GLUTAMIC ACID
roles:
chemical component
formula:
C2 H5 N O2
name:
GLYCINE
roles:
chemical component
formula:
C6 H10 N3 O2 1
name:
HISTIDINE
roles:
chemical component
formula:
C6 H13 N O2
name:
ISOLEUCINE
roles:
chemical component
formula:
C6 H13 N O2
name:
LEUCINE
roles:
chemical component
formula:
C6 H15 N2 O2 1
name:
LYSINE
roles:
chemical component
formula:
C5 H11 N O2 S
name:
METHIONINE
roles:
chemical component
formula:
C9 H11 N O2
name:
PHENYLALANINE
roles:
chemical component
formula:
C5 H9 N O2
name:
PROLINE
roles:
chemical component
formula:
C3 H7 N O3
name:
SERINE
roles:
chemical component
formula:
O4 S -2
name:
SULFATE ION
roles:
chemical component
formula:
C28 H26 N4 O3
name:
STAUROSPORINE
roles:
chemical component
formula:
C4 H9 N O3
name:
THREONINE
roles:
chemical component
formula:
C4 H10 N O6 P
name:
PHOSPHOTHREONINE
roles:
chemical component
formula:
C11 H12 N2 O2
name:
TRYPTOPHAN
roles:
chemical component
formula:
C9 H11 N O3
name:
TYROSINE
roles:
chemical component
formula:
C5 H11 N O2
name:
VALINE
roles:
chemical component
name:
Prkaa1, Ampk1
name:
Prkab1
name:
Prkag1
name:
X-RAY DIFFRACTION
ID:
pdb:5T5T
ID:
wwpdb:D_1000223770
accessURL: https://files.rcsb.org/download/5T5T.xml.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBML/XML
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5T5T.pdb.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5T5T.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBx/mmCIF
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=5T5T
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
FASTA
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5T5T-sf.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
CIF
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/5T5T.pdb1.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format (A)
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=5T5T&bionumber=1
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
JSmol
accessType:
view
authentication:
none
authorization:
none
abbreviation:
wwPDB
homePage: http://www.wwpdb.org
ID:
SCR:006555
name:
Worldwide Protein Data Bank
abbreviation:
PDB
homePage: http://www.rcsb.org/pdb/
ID:
SCR:012820
name:
Protein Data Bank