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Title: Crystal structure of Galphaq in complex with full-length human PLCbeta3      
description:
Guanine nucleotide-binding protein G(q) subunit alpha, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (E.C.3.1.4.11)
privacy:
not applicable
aggregation:
instance of dataset
ID:
PDB:4GNK
refinement:
curated
keywords:
GTP-BINDING PROTEIN/HYDROLASE
GTP-binding protein alpha subunits
phospholipase C beta
coiled-coil domain
PH DOMAIN
EF HAND
C2 DOMAIN
TIM BARREL DOMAIN
phospholipase
GTP hydrolysis
G-protein signaling
membrane targeting
lipase
hydrolase
calcium binding
GTP binding
phospholipids
GTP-BINDING PROTEIN-HYDROLASE complex
creators:
Lyon, A.M.
Dutta, S.
Boguth, C.A.
Skiniotis, G.
Tesmer, J.J.
availability:
available
types:
structure
name:
Mus musculus
ID:
ncbitax:10090
name:
Homo sapiens
ID:
ncbitax:9606
name:
Homo sapiens
ID:
ncbitax:9606
name:
Trichoplusia ni
ID:
ncbitax:7111
name:
Trichoplusia ni
ID:
ncbitax:7111
name:
Trichoplusia ni
ID:
ncbitax:7111
authors:
Lyon, A.M.
Dutta, S.
Boguth, C.A.
Skiniotis, G.
Tesmer, J.J.
alternateID:
doi:10.1038/nsmb.2497
year:
2013
ID: pmid:23377541
title:
Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
formula:
C3 H7 N O2
name:
ALANINE
roles:
chemical component
formula:
C6 H15 N4 O2 1
name:
ARGININE
roles:
chemical component
formula:
C6 H13 N O2
name:
ISOLEUCINE
roles:
chemical component
formula:
C4 H8 N2 O3
name:
ASPARAGINE
roles:
chemical component
formula:
C4 H7 N O4
name:
ASPARTIC ACID
roles:
chemical component
formula:
C5 H9 N O4
name:
GLUTAMIC ACID
roles:
chemical component
formula:
C5 H10 N2 O3
name:
GLUTAMINE
roles:
chemical component
formula:
C6 H13 N O2
name:
LEUCINE
roles:
chemical component
formula:
C6 H15 N2 O2 1
name:
LYSINE
roles:
chemical component
formula:
C2 H5 N O2
name:
GLYCINE
roles:
chemical component
formula:
C4 H9 N O3
name:
THREONINE
roles:
chemical component
formula:
C3 H7 N O3
name:
SERINE
roles:
chemical component
formula:
C9 H11 N O2
name:
PHENYLALANINE
roles:
chemical component
formula:
C5 H11 N O2 S
name:
METHIONINE
roles:
chemical component
formula:
C6 H10 N3 O2 1
name:
HISTIDINE
roles:
chemical component
formula:
C9 H11 N O3
name:
TYROSINE
roles:
chemical component
formula:
C5 H11 N O2
name:
VALINE
roles:
chemical component
formula:
C5 H9 N O2
name:
PROLINE
roles:
chemical component
formula:
C11 H12 N2 O2
name:
TRYPTOPHAN
roles:
chemical component
formula:
C3 H7 N O2 S
name:
CYSTEINE
roles:
chemical component
formula:
C10 H15 N5 O11 P2
name:
GUANOSINE-5'-DIPHOSPHATE
roles:
chemical component
formula:
AL F4 -1
name:
TETRAFLUOROALUMINATE ION
roles:
chemical component
formula:
MG 2
name:
MAGNESIUM ION
roles:
chemical component
formula:
CA 2
name:
CALCIUM ION
roles:
chemical component
formula:
H2 O
name:
WATER
roles:
chemical component
name:
g alpha q, Gnaq
name:
phospholipase c beta 3, PLCB3
name:
phospholipase c beta 3, PLCB3
name:
X-RAY DIFFRACTION
ID:
pdb:4GNK
ID:
rcsb:RCSB074407
accessURL: https://files.rcsb.org/download/4GNK.xml.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBML/XML
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4GNK.pdb.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4GNK.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDBx/mmCIF
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=4GNK
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
FASTA
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4GNK-sf.cif.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
CIF
accessType:
download
authentication:
none
authorization:
none
accessURL: https://files.rcsb.org/download/4GNK.pdb1.gz
storedIn:
Protein Data Bank
qualifier:
gzip compressed
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
PDB Format (A)
accessType:
download
authentication:
none
authorization:
none
accessURL: http://www.rcsb.org/pdb/explore/jmol.do?structureId=4GNK&bionumber=1
storedIn:
Protein Data Bank
license:
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data. By using the materials available in the PDB archive, the user agrees to abide by the conditions described in the PDB Advisory Notice.
format:
JSmol
accessType:
view
authentication:
none
authorization:
none
abbreviation:
wwPDB
homePage: http://www.wwpdb.org
ID:
SCR:006555
name:
Worldwide Protein Data Bank
abbreviation:
PDB
homePage: http://www.rcsb.org/pdb/
ID:
SCR:012820
name:
Protein Data Bank
  • Y1-GM-1104/GM/NIGMS NIH HHS/United States

  • HL086865,/HL/NHLBI NIH HHS/United States

  • GM081655/GM/NIGMS NIH HHS/United States

  • R01 DK090165/DK/NIDDK NIH HHS/United States

  • P30 CA046592/CA/NCI NIH HHS/United States

  • HL071818/HL/NHLBI NIH HHS/United States

  • R01 HL086865/HL/NHLBI NIH HHS/United States

  • P60 DK020572/DK/NIDDK NIH HHS/United States

  • DK20572./DK/NIDDK NIH HHS/United States

  • Y1-CO-1020/CO/NCI NIH HHS/United States

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