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Title: Brain Metastases in Squamous Cell Lung Cancers      
citations:
25929848
description:
Putative oncogenic pathways in squamous cell lung cancer have been recently characterized, although their biologic repercussions in patients is largely unknown. This study sought to discover potential clinical manifestations of major pathways in squamous cell lung cancer, particularly the PI3K pathway. Two key findings emerged: patients with stage IV squamous cell lung cancer whose tumors harbored upstream PI3K aberrations had significantly worse survival and a higher burden of metastatic disease. In addition, brain metastases were significantly more common in these patients than in others. Paired lung primary/brain metastasis genotyping, including RNA sequencing and whole exome sequencing, uncovered a high degree of genetic heterogeneity between lung/brain pairs, and identified potential regulators of the metastatic process to brain.
Identifier:
phs000907.v1.p1
accesstypes:
download
enclave
landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000907.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Squamous Cell Carcinoma
Nonsmall Cell Lung Cancer
affiliations:
Memorial Sloan Kettering Cancer Center, New York, NY, USA
name:
Paul K. Paik, MD
roles:
Principal Investigator
affiliations:
Conquer Cancer Foundation, Alexandria, VA, USA
name:
Conquer Cancer Foundation Awards
roles:
Funding Source
performedBy:
TitleNameInstitute Principal InvestigatorPaul K. Paik, MDMemorial Sloan Kettering Cancer Center, New York, NY, USA Funding SourceConquer Cancer Foundation AwardsConquer Cancer Foundation, Alexandria, VA, USA
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000907.v1.p1
Identifier:
phs000907.v1.p1_policy
name:
Data Use Certificate
Identifier:
1
name:
Disease-Specific (Cancer)
alternateIdentifiers:
yes
selectionCriteria:

Inclusion criteria: 1) Signed an institutional biospecimen utilization protocol (MSK IRB 06-107) 2) Stage IV squamous cell lung cancer pathologic diagnosis 3) Availability of respected brain metastasis and lung primary tumor

types:
Case Set
dateReleased:
04-28-2015
version:
phs000907.v1.p1
dateModified:
02-25-2016
abbreviation:
NCI
name:
NCI
ID:
0
name:
dbGaP