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Title: Family Genomics of Bipolar Disorder      
citations:
21769101
19488044
25730879
description:
This study examined the segregation of variants with phenotype in pedigrees harboring bipolar disorder.
Identifier:
phs000866.v1.p1
accesstypes:
download
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landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000866.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Bipolar Disorder
affiliations:
Institute for Systems Biology
name:
Jared Roach
roles:
Principal Investigator
affiliations:
University of California, San Diego, CA, USA
name:
John Kelsoe
roles:
Principal Investigator
affiliations:
National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
name:
Francis McMahon
roles:
Principal Investigator
affiliations:
University of Luxembourg, Institute for Systems Biology, EU
name:
University of Luxembourg - Institute for Systems Biology Program
roles:
Funding Source
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
National Institute of General Medical Sciences Center for Systems Biology P50 GM076547
roles:
Funding Source
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
National Institute of Mental Health (NIMH) R01 MH094483
roles:
Funding Source
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
Intramural Research Program of the NIMH
roles:
Funding Source
affiliations:
Life Sciences Research Foundation
name:
Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
roles:
Funding Source
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
Data and biomaterials were collected as part of eleven projects (Study 40) that participated in the NIMH Bipolar Disorder Genetics Initiative (MH59545, MH059534, MH59533, MH59553, MH60068, MH059548, MH59535, MH59567, MH059556, and 1Z01MH002810-01), which was also supported by the NIH grants P50CA89392 from the National Cancer Institute and 5K02DA021237 from the National Institute of Drug Abuse
roles:
Funding Source
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
Biomaterials and phenotypic data were obtained for control subjects from the NIMH Schizophrenia Genetics Initiative (NIMH-GI), which were collected by the "Molecular Genetics of Schizophrenia II" (MGS-2) collaboration
roles:
Funding Source
performedBy:
TitleNameInstitute Principal InvestigatorJared RoachInstitute for Systems Biology Principal InvestigatorJohn KelsoeUniversity of California, San Diego, CA, USA Principal InvestigatorFrancis McMahonNational Institute of Mental Health, National Institute of Health, Bethesda, MD, USA Funding SourceUniversity of Luxembourg - Institute for Systems Biology ProgramUniversity of Luxembourg, Institute for Systems Biology, EU Funding SourceNational Institute of General Medical Sciences Center for Systems Biology P50 GM076547National Institutes of Health, Bethesda, MD, USA
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000866.v1.p1
Identifier:
phs000866.v1.p1_policy
name:
Data Use Certificate
Identifier:
1
name:
Disease-Specific (Psychiatric Disorders and Related Somatic Conditions, RD)
schedulesActivity:
The bipolar disorder pedigrees sequenced in this study were drawn from a set of 972 multiply affected pedigrees collected by the NIMH Genetics Initiative and by sites at the University of California, San Diego, the University of California, San Francisco, and the University of Chicago. This sample has been described in Badner JA, et al. (2012) Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry 17(8):818-826. DNA derived from whole blood or from lymphoblastoid cell lines was obtained from the Rutgers University Cell and DNA Repository and from the Corriell Institute. We selected pedigrees and individuals for sequencing by considering family structure, per-pedigree LOD scores at 4,500 genome-wide SNPs, and the polygenic risk score in each pedigree's proband: Smith EN, et al. (2009) Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 14(8):755-763.
alternateIdentifiers:
yes
selectionCriteria:

We chose a subset of individuals within each pedigree so as to maximize power under the most likely inheritance mode, as follows: (i) We sequenced a single affected individual and a single unaffected individual from pedigrees with a suggestive per-pedigree linkage peak and predicted dominant inheritance. (ii) We sequenced a parent-child trio or quartet from pedigrees with a single, suggestive per-pedigree linkage peak and either dominant or recessive inheritance. In pedigrees for which polygenic inheritance was more likely, we sequenced either (iii) a subset of affected individuals and 0-1 unaffected individuals or (iv) all available individuals.

types:
Family
dateReleased:
02-04-2015
version:
phs000866.v1.p1
dateModified:
03-23-2015
abbreviation:
NIMH
name:
NIMH
ID:
0
name:
dbGaP