Title:

Collaborative Study of Genes, Nutrients and Metabolites (CSGNM)

citations:	21653798 23267103
description:	While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand the influence of genetic variants on circulating metabolites and factors in normal, healthy individuals. Over 2500 healthy, ethnically Irish college students attending Trinity College Dublin completed a health and diet questionnaire and provided a non-fasting blood sample to be used for genetic and metabolic analysis. The questionnaire was designed to collect information on age, sex, height, weight, medical conditions, smoking, dietary habits, and consumption of alcohol, fortified foods, and supplements. Extracted DNA was genotyped using the Illumina HumanOmni1-Quad Beadchip. Metabolites were measured using a number of methods and focused on those relevant to the folate/vitamin B12 pathway.
Identifier:	phs000789.v1.p1

accesstypes:	download enclave
landingpage:	http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000789.v1.p1
authentication:	simpleLogin none
authorization:	none duaIndividual

name:	Body Height Body Weight Age Distribution Sex Birth place Race Cotinine Creatinine Leukocyte count Erythrocyte Count Hemoglobins hematocrit Mean corpuscular volume Mean corpuscular hemoglobin Mean Corpuscular Hemoglobin Concentration Platelet count Aspartate aminotransferase Alanine Transaminase Gamma-glutamyltransferase Bilirubin Urea Uric Acid Ferritins Vitamin B 12 Holo transcobalamin II Transcobalamin II Homocysteine Methylmalonic acid Cysteine Methionine Serine Glycine Cystathionine Sarcosine Arginine Tryptophan Kynurenine 3-Hydroxykynurenine Kynurenic acid Xanthurenic acid Anthranilic acids 3-Hydroxyanthranilic acid Neopterin Choline Betaine Dimethylglycine Pyridoxal phosphate Pyridoxal Pyridoxic acid Riboflavin Flavin mononucleotide Flavin-Adenine Dinucleotide

affiliations:	National Institutes of Health, Bethesda, MD, USA
name:	Lawrence Brody, PhD
roles:	Co-Investigators
affiliations:	Trinity College, Dublin, Ireland
name:	Anne Molloy, PhD
roles:	Co-Investigators
affiliations:	National Institutes of Health, Bethesda, MD, USA
name:	James Mills, MD
roles:	Co-Investigators
affiliations:	University of Bergen, Norway
name:	Per Magne Ueland, MD
roles:	Co-Investigators
affiliations:	Trinity College, Dublin, Ireland
name:	John Scott, ScD
roles:	Co-Investigators

performedBy:	TitleNameInstitute Co-InvestigatorsLawrence Brody, PhDNational Institutes of Health, Bethesda, MD, USA Co-InvestigatorsAnne Molloy, PhDTrinity College, Dublin, Ireland Co-InvestigatorsJames Mills, MDNational Institutes of Health, Bethesda, MD, USA Co-InvestigatorsPer Magne Ueland, MDUniversity of Bergen, Norway Co-InvestigatorsJohn Scott, ScDTrinity College, Dublin, Ireland

downloadURL:	https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000789.v1.p1
Identifier:	phs000789.v1.p1_policy
name:	Data Use Certificate

Identifier:	0
name:	Subjects did not participate in the study, did not complete a consent document and are included only for the pedigree structure and/or genotype controls, such as HapMap subjects
Identifier:	1
name:	Health/Medical/Biomedical

alternateIdentifiers:	yes
selectionCriteria:	Exclusion: At least one grandparent not born in Republic of Ireland or Northern Ireland. Exclusion: Any major medical health problem. Inclusion: Ages 18-28.
types:	Control Set

abbreviation:	NHGRI
name:	National Human Genome Research Institute
ID:	0

name:	dbGaP

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