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Title: Collaborative Study of Genes, Nutrients and Metabolites (CSGNM)      
citations:
21653798
23267103
description:
While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand the influence of genetic variants on circulating metabolites and factors in normal, healthy individuals. Over 2500 healthy, ethnically Irish college students attending Trinity College Dublin completed a health and diet questionnaire and provided a non-fasting blood sample to be used for genetic and metabolic analysis. The questionnaire was designed to collect information on age, sex, height, weight, medical conditions, smoking, dietary habits, and consumption of alcohol, fortified foods, and supplements. Extracted DNA was genotyped using the Illumina HumanOmni1-Quad Beadchip. Metabolites were measured using a number of methods and focused on those relevant to the folate/vitamin B12 pathway.
Identifier:
phs000789.v1.p1
accesstypes:
download
enclave
landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000789.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Body Height
Body Weight
Age Distribution
Sex
Birth place
Race
Cotinine
Creatinine
Leukocyte count
Erythrocyte Count
Hemoglobins
hematocrit
Mean corpuscular volume
Mean corpuscular hemoglobin
Mean Corpuscular Hemoglobin Concentration
Platelet count
Aspartate aminotransferase
Alanine Transaminase
Gamma-glutamyltransferase
Bilirubin
Urea
Uric Acid
Ferritins
Vitamin B 12
Holo transcobalamin II
Transcobalamin II
Homocysteine
Methylmalonic acid
Cysteine
Methionine
Serine
Glycine
Cystathionine
Sarcosine
Arginine
Tryptophan
Kynurenine
3-Hydroxykynurenine
Kynurenic acid
Xanthurenic acid
Anthranilic acids
3-Hydroxyanthranilic acid
Neopterin
Choline
Betaine
Dimethylglycine
Pyridoxal phosphate
Pyridoxal
Pyridoxic acid
Riboflavin
Flavin mononucleotide
Flavin-Adenine Dinucleotide
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
Lawrence Brody, PhD
roles:
Co-Investigators
affiliations:
Trinity College, Dublin, Ireland
name:
Anne Molloy, PhD
roles:
Co-Investigators
affiliations:
National Institutes of Health, Bethesda, MD, USA
name:
James Mills, MD
roles:
Co-Investigators
affiliations:
University of Bergen, Norway
name:
Per Magne Ueland, MD
roles:
Co-Investigators
affiliations:
Trinity College, Dublin, Ireland
name:
John Scott, ScD
roles:
Co-Investigators
performedBy:
TitleNameInstitute Co-InvestigatorsLawrence Brody, PhDNational Institutes of Health, Bethesda, MD, USA Co-InvestigatorsAnne Molloy, PhDTrinity College, Dublin, Ireland Co-InvestigatorsJames Mills, MDNational Institutes of Health, Bethesda, MD, USA Co-InvestigatorsPer Magne Ueland, MDUniversity of Bergen, Norway Co-InvestigatorsJohn Scott, ScDTrinity College, Dublin, Ireland
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000789.v1.p1
Identifier:
phs000789.v1.p1_policy
name:
Data Use Certificate
Identifier:
0
name:
Subjects did not participate in the study, did not complete a consent document and are included only for the pedigree structure and/or genotype controls, such as HapMap subjects
Identifier:
1
name:
Health/Medical/Biomedical
alternateIdentifiers:
yes
selectionCriteria:

Exclusion: At least one grandparent not born in Republic of Ireland or Northern Ireland.
Exclusion: Any major medical health problem.
Inclusion: Ages 18-28.

types:
Control Set
dateReleased:
08-18-2014
version:
phs000789.v1.p1
dateModified:
08-18-2014
abbreviation:
NHGRI
name:
National Human Genome Research Institute
ID:
0
name:
dbGaP

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