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Title: Framingham Cohort      
Identifier:
phs000007.v29.p10
description:
Startup of Framingham Heart Study. Cardiovascular disease (CVD) is the leading cause of death and serious illness in the United States. In 1948, the Framingham Heart Study (FHS) -- under the direction of the National Heart Institute (now known as the National Heart, Lung, and Blood Institute, NHLBI) -- embarked on a novel and ambitious project in health research. At the time, little was known about the general causes of heart disease and stroke, but the death rates for CVD had been increasing steadily since the beginning of the century and had become an American epidemic. The objective of the FHS was to identify the common factors or characteristics that contribute to CVD by following its development over a long period of time in a large group of participants who had not yet developed overt symptoms of CVD or suffered a heart attack or stroke. Design of Framingham Heart Study. In 1948, the researchers recruited 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, and began the first round of extensive physical examinations and lifestyle interviews that they would later analyze for common patterns related to CVD development. Since 1948, the subjects have returned to the study every two years for an examination consisting of a detailed medical history, physical examination, and laboratory tests, and in 1971, the study enrolled a second-generation cohort -- 5,124 of the original participants' adult children and their spouses -- to participate in similar examinations. The second examination of the Offspring cohort occurred eight years after the first examination, and subsequent examinations have occurred approximately every four years thereafter. In April 2002 the Study entered a new phase: the enrollment of a third generation of participants, the grandchildren of the original cohort. The first examination of the Third Generation Study was completed in July 2005 and involved 4,095 participants. Thus, the FHS has evolved into a prospective, community-based, three generation family study. The FHS is a joint project of the National Heart, Lung and Blood Institute and Boston University. Research Areas in the Framingham Heart Study. Over the years, careful monitoring of the FHS population has led to the identification of the major CVD risk factors -- high blood pressure, high blood cholesterol, smoking, obesity, diabetes, and physical inactivity -- as well as a great deal of valuable information on the effects of related factors such as blood triglyceride and HDL cholesterol levels, age, gender, and psychosocial issues. Risk factors have been identified for the major components of CVD, including coronary heart disease, stroke, intermittent claudication, and heart failure. It is also clear from research in the FHS and other studies that substantial subclinical vascular disease occurs in the blood vessels, heart and brain that precedes clinical CVD. With recent advances in technology, the FHS has enhanced its research capabilities and capitalized on its inherent resources by the conduct of high resolution imaging to detect and quantify subclinical vascular disease in the major blood vessels, heart and brain. These studies have included ultrasound studies of the heart (echocardiography) and carotid arteries, computed tomography studies of the heart and aorta, and magnetic resonance imaging studies of the brain, heart, and aorta. Although the Framingham cohort is primarily white, the importance of the major CVD risk factors identified in this group have been shown in other studies to apply almost universally among racial and ethnic groups, even though the patterns of distribution may vary from group to group. In the past half century, the Study has produced approximately 1,200 articles in leading medical journals. The concept of CVD risk factors has become an integral part of the modern medical curriculum and has led to the development of effective treatment and preventive strategies in clinical practice. In addition to research studies focused on risk factors, subclinical CVD and clinically apparent CVD, Framingham investigators have also collaborated with leading researchers from around the country and throughout the world on projects involving some of the major chronic illnesses in men and women, including dementia, osteoporosis and arthritis, nutritional deficiencies, eye diseases, hearing disorders, and chronic obstructive lung diseases. Genetic Research in the Framingham Heart Study. While pursuing the Study's established research goals, the NHLBI and the Framingham investigators has expanded its research mission into the study of genetic factors underlying CVD and other disorders. Over the past two decades, DNA has been collected from blood samples and from immortalized cell lines obtained from Original Cohort participants, members of the Offspring Cohort and the Third Generation Cohort. Several large-scale genotyping projects have been conducted in the past decade. Genome-wide linkage analysis has been conducted using genotypes of approximately 400 microsatellite markers that have been completed in over 9,300 subjects in all three generations. Analyses using microsatellite markers completed in the original cohort and offspring cohorts have resulted in over 100 publications, including many publications from the Genetics Analysis Workshop 13. Several other recent collaborative projects have completed thousands of SNP genotypes for candidate gene regions in subsets of FHS subjects with available DNA. These projects include the Cardiogenomics Program of the NHLBI's Programs for Genomics Applications, the genotyping of ~3000 SNPs in inflammation genes, and the completion of a genome-wide scan of 100,000 SNPs using the Affymetrix 100K Genechip. Framingham Cohort Phenotype Data. The phenotype database contains a vast array of phenotype information available in all three generations. These will include the quantitative measures of the major risk factors such as systolic blood pressure, total and HDL cholesterol, fasting glucose, and cigarette use, as well as anthropomorphic measures such as body mass index, biomarkers such as fibrinogen and CRP, and electrocardiography measures such as the QT interval. Many of these measures have been collected repeatedly in the original and offspring cohorts. Also included in the SHARe database will be an array of recently collected biomarkers, subclinical disease imaging measures, clinical CVD outcomes as well as an array of ancillary studies. The phenotype data is located here in the top-level study phs000007 Framingham Cohort. To view the phenotype variables collected from the Framingham Cohort, please click on the "Variables" tab above. The Framingham Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs000007 Framingham Cohort. phs000342 Framingham SHARe phs000282 Framingham CARe phs000363 Framingham SABRe phs000307 Framingham Medical Resequencing phs000401 Framingham ESP Heart-GO phs000651 Framingham CHARGE-S phs000724 Framingham DNA Methylation The unflagging commitment of the research participants in the NHLBI FHS has made more than a half century of research success possible. For decades, the FHS has made its data and DNA widely available to qualified investigators throughout the world through the Limited Access Datasets and the FHS DNA Committee, and the SHARe database will continue that tradition by allowing access to qualified investigators who agree to the requirements of data access. With the SHARe database, we continue with an ambitious research agenda and look forward to new discoveries in the decades to come.
accesstypes:
download
enclave
landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000007.v29.p10
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Cardiovascular Diseases
Cardiovascular System
Dementia
Diabetes Mellitus
Stroke
Cholesterol
Heart Diseases
Heart Failure, Congestive
Hypertension
Intermittent Claudication
Myocardial Infarction
Obesity
Osteoporosis
Risk Factors
Smoking
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000007.v29.p10
Identifier:
phs000007.v29.p10_policy
name:
Data Use Certificate
Identifier:
0
name:
Subjects did not participate in the study, did not complete a consent document and are included only for the pedigree structure and/or genotype controls, such as HapMap subjects
Identifier:
1
name:
Health/Medical/Biomedical (IRB, MDS)
Identifier:
2
name:
Health/Medical/Biomedical (IRB, NPU, MDS)
schedulesActivity:
Research milestones of the Framingham Heart Study can be found at http://www.framinghamheartstudy.org/about/milestones.html. The Generation 1 (or Original) cohort Exam 1 took place between 1948 and 1953. Biennial exams have continued to the present. Exam 29 took place between 2006 and 2007. Exam 30 began in 2008. The Generation 2 (or Offspring) cohort Exam 1 took place between 1971 and 1975. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. Exam 8 took place between 2005 and 2008. The Generation 3 cohort Exam 1 took place between 2002 and 2005. Exam 2 began in 2008. The New Offspring Spouse cohort Exam 1 took place between 2003 and 2005. Exam 2 began in 2008.
alternateIdentifiers:
yes
selectionCriteria:

A description of the Design of the Original Cohort can be found at Dawber TR, Meadors GF, and Moore FEJ. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health 1951; 41:279-86.

A description of the Design of the Offspring Cohort can be found at Feinleib M, Kannel WB, Garrison RJ, et al. (1975) The Framingham Offspring Study. Design and preliminary data. Prev Med 4:518-25.

A description of the Design of the Third Generation Cohort can be found at Splansky GL et al. The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination. Am J Epidemioly 2007 Mar 19 [Epub ahead of print].

types:
Longitudinal
dateReleased:
07-26-2016
version:
phs000007.v29.p10
dateModified:
01-27-2017
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Association Testing GEE
Identifier:
347
Name:
Association Testing FBAT
Identifier:
348
Name:
Association Testing GEE
Identifier:
349
Name:
Association Testing FBAT
Identifier:
350
Name:
Association Testing GEE
Identifier:
351
Name:
Association Testing FBAT
Identifier:
352
Name:
Association Testing GEE
Identifier:
353
Name:
Association Testing FBAT
Identifier:
354
Name:
Association Testing GEE
Identifier:
355
Name:
Association Testing FBAT
Identifier:
356
Name:
Association Testing GEE
Identifier:
357
Name:
Association Testing FBAT
Identifier:
358
Name:
Association Testing GEE
Identifier:
359
Name:
Association Testing FBAT
Identifier:
360
Name:
Association Testing GEE
Identifier:
361
Name:
Association Testing FBAT
Identifier:
362
Name:
Association Testing GEE
Identifier:
363
Name:
Association Testing FBAT
Identifier:
364
Name:
Association Testing GEE
Identifier:
365
Name:
Association Testing FBAT
Identifier:
366
Name:
Association Testing GEE
Identifier:
367
Name:
Association Testing FBAT
Identifier:
368
Name:
Association Testing GEE
Identifier:
369
Name:
Association Testing FBAT
Identifier:
370
Name:
Association Testing GEE
Identifier:
371
Name:
Association Testing FBAT
Identifier:
372
Name:
Association Testing GEE
Identifier:
373
Name:
Association Testing FBAT
Identifier:
374
Name:
Association Testing GEE
Identifier:
375
Name:
Association Testing FBAT
Identifier:
376
Name:
Association Testing GEE
Identifier:
377
Name:
Association Testing FBAT
Identifier:
378
Name:
Association Testing GEE
Identifier:
379
Name:
Association Testing FBAT
Identifier:
380
Name:
Association Testing GEE
Identifier:
381
Name:
Association Testing FBAT
Identifier:
382
Name:
Association Testing GEE
Identifier:
383
Name:
Association Testing FBAT
Identifier:
384
Name:
Association Testing GEE
Identifier:
385
Name:
Association Testing FBAT
Identifier:
386
Name:
Association Testing GEE
Identifier:
387
Name:
Association Testing FBAT
Identifier:
388
Name:
Association Testing GEE
Identifier:
389
Name:
Association Testing FBAT
Identifier:
390
Name:
Association Testing GEE
Identifier:
391
Name:
Association Testing FBAT
Identifier:
392
Name:
Association Testing GEE
Identifier:
393
Name:
Association Testing FBAT
Identifier:
394
Name:
Association Testing GEE
Identifier:
395
Name:
Association Testing FBAT
Identifier:
396
Name:
Association Testing GEE
Identifier:
397
Name:
Association Testing FBAT
Identifier:
398
Name:
Association Testing GEE
Identifier:
399
Name:
Association Testing FBAT
Identifier:
400
Name:
Association Testing GEE
Identifier:
401
Name:
Association Testing FBAT
Identifier:
402
Name:
Association Testing GEE
Identifier:
403
Name:
Association Testing FBAT
Identifier:
404
Name:
Association Testing GEE
Identifier:
405
Name:
Association Testing FBAT
Identifier:
406
Name:
Association Testing GEE
Identifier:
407
Name:
Association Testing FBAT
Identifier:
408
Name:
Association Testing GEE
Identifier:
409
Name:
Association Testing FBAT
Identifier:
410
Name:
Association Testing GEE
Identifier:
411
Name:
Association Testing FBAT
Identifier:
412
Name:
Association Testing GEE
Identifier:
413
Name:
Association Testing FBAT
Identifier:
414
Name:
Association Testing GEE
Identifier:
415
Name:
Association Testing FBAT
Identifier:
416
Name:
Association Testing GEE
Identifier:
417
Name:
Association Testing FBAT
Identifier:
418
Name:
Association Testing GEE
Identifier:
419
Name:
Association Testing FBAT
Identifier:
420
Name:
Association Testing GEE
Identifier:
421
Name:
Association Testing FBAT
Identifier:
422
Name:
Association Testing GEE
Identifier:
423
Name:
Association Testing FBAT
Identifier:
424
Name:
Association Testing GEE
Identifier:
425
Name:
Association Testing FBAT
Identifier:
426
Name:
Association Testing GEE
Identifier:
427
Name:
Association Testing FBAT
Identifier:
428
Name:
Association Testing GEE
Identifier:
429
Name:
Association Testing FBAT
Identifier:
430
Name:
Association Testing GEE
Identifier:
431
Name:
Association Testing FBAT
Identifier:
432
Name:
Association Testing GEE
Identifier:
433
Name:
Association Testing FBAT
Identifier:
434
Name:
Association Testing GEE
Identifier:
435
Name:
Association Testing FBAT
Identifier:
436
Name:
Association Testing GEE
Identifier:
437
Name:
Association Testing FBAT
Identifier:
438
Name:
Association Testing GEE
Identifier:
439
Name:
Association Testing FBAT
Identifier:
440
Name:
Association Testing GEE
Identifier:
441
Name:
Association Testing FBAT
Identifier:
442
Name:
Association Testing GEE
Identifier:
443
Name:
Association Testing FBAT
Identifier:
444
Name:
Association Testing GEE
Identifier:
445
Name:
Association Testing FBAT
Identifier:
446
Name:
Association Testing GEE
Identifier:
447
Name:
Association Testing FBAT
Identifier:
448
Name:
Association Testing GEE
Identifier:
449
Name:
Association Testing FBAT
Identifier:
450
Name:
Association Testing GEE
Identifier:
451
Name:
Association Testing FBAT
Identifier:
452
Name:
Association Testing GEE
Identifier:
453
Name:
Association Testing FBAT
Identifier:
454
Name:
Association Testing GEE
Identifier:
455
Name:
Association Testing FBAT
Identifier:
456
Name:
Association Testing GEE
Identifier:
457
Name:
Association Testing FBAT
Identifier:
458
Name:
Association Testing GEE
Identifier:
459
Name:
Association Testing FBAT
Identifier:
460
Name:
Association Testing GEE
Identifier:
461
Name:
Association Testing FBAT
Identifier:
462
Name:
Association Testing GEE
Identifier:
463
Name:
Association Testing FBAT
Identifier:
464
Name:
Association Testing GEE
Identifier:
465
Name:
Association Testing FBAT
Identifier:
466
Name:
Association Testing GEE
Identifier:
467
Name:
Association Testing FBAT
Identifier:
468
Name:
Association Testing GEE
Identifier:
469
Name:
Association Testing FBAT
Identifier:
470
Name:
Association Testing GEE
Identifier:
471
Name:
Association Testing FBAT
Identifier:
472
Name:
Association Testing GEE
Identifier:
473
Name:
Association Testing FBAT
Identifier:
474
Name:
Association Testing GEE
Identifier:
475
Name:
Association Testing FBAT
Identifier:
476
Name:
Association Testing GEE
Identifier:
477
Name:
Association Testing FBAT
Identifier:
478
Name:
Association Testing GEE
Identifier:
479
Name:
Association Testing FBAT
Identifier:
480
Name:
Association Testing GEE
Identifier:
481
Name:
Association Testing FBAT
Identifier:
482
Name:
Association Testing GEE
Identifier:
483
Name:
Association Testing FBAT
Identifier:
484
Name:
Association Testing GEE
Identifier:
485
Name:
Association Testing FBAT
Identifier:
486
Name:
Association Testing GEE
Identifier:
487
Name:
Association Testing FBAT
Identifier:
488
Name:
Association Testing GEE
Identifier:
489
Name:
Association Testing FBAT
Identifier:
490
Name:
Association Testing GEE
Identifier:
491
Name:
Association Testing FBAT
Identifier:
492
Name:
Association Testing GEE
Identifier:
493
Name:
Association Testing FBAT
Identifier:
494
Name:
Association Testing GEE
Identifier:
495
Name:
Association Testing FBAT
Identifier:
496
Name:
Association Testing GEE
Identifier:
497
Name:
Association Testing FBAT
Identifier:
498
Name:
Association Testing GEE
Identifier:
499
Name:
Association Testing FBAT
Identifier:
500
Name:
Association Testing GEE
Identifier:
501
Name:
Association Testing FBAT
Identifier:
502
Name:
Association Testing GEE
Identifier:
503
Name:
Association Testing FBAT
Identifier:
504
Name:
Association Testing GEE
Identifier:
505
Name:
Association Testing FBAT
Identifier:
506
Name:
Association Testing GEE
Identifier:
507
Name:
Association Testing FBAT
Identifier:
508
Name:
Association Testing GEE
Identifier:
509
Name:
Association Testing FBAT
Identifier:
510
Name:
Association Testing GEE
Identifier:
511
Name:
Association Testing FBAT
Identifier:
512
Name:
Association Testing GEE
Identifier:
513
Name:
Association Testing FBAT
Identifier:
514
Name:
Association Testing GEE
Identifier:
515
Name:
Association Testing FBAT
Identifier:
516
Name:
Association Testing GEE
Identifier:
517
Name:
Association Testing FBAT
Identifier:
518
Name:
Association Testing GEE
Identifier:
519
Name:
Association Testing FBAT
Identifier:
520
Name:
Association Testing GEE
Identifier:
521
Name:
Association Testing FBAT
Identifier:
522
Name:
Association Testing GEE
Identifier:
523
Name:
Association Testing FBAT
Identifier:
524
Name:
Association Testing GEE
Identifier:
525
Name:
Association Testing FBAT
Identifier:
526
Name:
Association Testing GEE
Identifier:
527
Name:
Association Testing FBAT
Identifier:
528
Name:
Association Testing GEE
Identifier:
529
Name:
Association Testing FBAT
Identifier:
530
Name:
Association Testing GEE
Identifier:
531
Name:
Association Testing FBAT
Identifier:
532
Name:
Association Testing GEE
Identifier:
533
Name:
Association Testing FBAT
Identifier:
534
Name:
Association Testing GEE
Identifier:
535
Name:
Association Testing FBAT
Identifier:
536
Name:
Association Testing GEE
Identifier:
537
Name:
Association Testing FBAT
Identifier:
538
Name:
Association Testing GEE
Identifier:
539
Name:
Association Testing FBAT
Identifier:
540
Name:
Association Testing GEE
Identifier:
541
Name:
Association Testing FBAT
Identifier:
542
Name:
Association Testing GEE
Identifier:
543
Name:
Association Testing FBAT
Identifier:
544
Name:
Association Testing GEE
Identifier:
545
Name:
Association Testing FBAT
Identifier:
546
Name:
Association Testing GEE
Identifier:
547
Name:
Association Testing FBAT
Identifier:
548
Name:
Association Testing GEE
Identifier:
549
Name:
Association Testing FBAT
Identifier:
550
Name:
Association Testing GEE
Identifier:
551
Name:
Association Testing FBAT
Identifier:
552
Name:
Association Testing GEE
Identifier:
553
Name:
Association Testing FBAT
Identifier:
554
Name:
Association Testing GEE
Identifier:
555
Name:
Association Testing FBAT
Identifier:
556
Name:
Association Testing GEE
Identifier:
557
Name:
Association Testing FBAT
Identifier:
558
Name:
Association Testing GEE
Identifier:
559
Name:
Association Testing FBAT
Identifier:
560
Name:
Association Testing GEE
Identifier:
561
Name:
Association Testing FBAT
Identifier:
562
Name:
Association Testing GEE
Identifier:
563
Name:
Association Testing FBAT
Identifier:
564
Name:
Association Testing GEE
Identifier:
565
Name:
Association Testing FBAT
Identifier:
566
Name:
Association Testing GEE
Identifier:
567
Name:
Association Testing FBAT
Identifier:
568
Name:
Association Testing GEE
Identifier:
569
Name:
Association Testing FBAT
Identifier:
570
Name:
Association Testing GEE
Identifier:
571
Name:
Association Testing FBAT
Identifier:
572
Name:
Association Testing GEE
Identifier:
573
Name:
Association Testing FBAT
Identifier:
574
Name:
Association Testing GEE
Identifier:
575
Name:
Association Testing FBAT
Identifier:
576
Name:
Association Testing GEE
Identifier:
577
Name:
Association Testing FBAT
Identifier:
578
Name:
Association Testing GEE
Identifier:
579
Name:
Association Testing FBAT
Identifier:
580
Name:
Association Testing GEE
Identifier:
581
Name:
Association Testing FBAT
Identifier:
582
Name:
Association Testing GEE
Identifier:
583
Name:
Association Testing FBAT
Identifier:
584
Name:
Association Testing GEE
Identifier:
585
Name:
Association Testing FBAT
Identifier:
586
Name:
Association Testing GEE
Identifier:
587
Name:
Association Testing FBAT
Identifier:
588
Name:
Association Testing GEE
Identifier:
589
Name:
Association Testing FBAT
Identifier:
590
Name:
Association Testing GEE
Identifier:
591
Name:
Association Testing FBAT
Identifier:
592
Name:
Association Testing GEE
Identifier:
593
Name:
Association Testing FBAT
Identifier:
594
Name:
Association Testing GEE
Identifier:
595
Name:
Association Testing FBAT
Identifier:
596
Name:
Association Testing GEE
Identifier:
597
Name:
Association Testing FBAT
Identifier:
598
Name:
Association Testing GEE
Identifier:
599
Name:
Association Testing FBAT
Identifier:
600
Name:
Association Testing GEE
Identifier:
601
Name:
Association Testing FBAT
Identifier:
602
Name:
Association Testing GEE
Identifier:
603
Name:
Association Testing FBAT
Identifier:
604
Name:
Association Testing GEE
Identifier:
605
Name:
Association Testing FBAT
Identifier: