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Title: Characterization of Pancreatic Adenocarcinoma Patients Using NGS      
citations:
23071490
description:
In this study, we whole genome sequenced tumor/normal pairs from three pancreatic adenocarcinoma patients to separately characterize each patient with respect to somatic alterations. For 2 patients for whom tumor RNA was available, we also performed RNA sequencing to evaluate gene expression changes. While additional sequencing is needed to improve our understanding of the disease, the information acquired from this study contributes to our knowledge base on pancreatic cancer and helps to establish a foundation for identifying and developing more efficacious treatments for patients.
Identifier:
phs000550.v1.p1
accesstypes:
download
enclave
landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000550.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Pancreatic Neoplasms
Carcinoma
affiliations:
Translational Genomics Research Institute, Phoenix, AZ, USA
name:
Winnie S. Liang, PhD
roles:
Principal Investigator
affiliations:
Translational Genomics Research Institute, Phoenix, AZ, USA
name:
David W. Craig, PhD
roles:
Co-Investigator
affiliations:
Translational Genomics Research Institute, Phoenix, AZ, USA
name:
John Carpten, PhD
roles:
Co-Investigator
affiliations:
Translational Genomics Research Institute, Phoenix, AZ, USA
name:
Mitesh J. Borad, MD
roles:
Co-Investigator
affiliations:
Translational Genomics Research Institute, Phoenix, AZ, USA
name:
Daniel Von Hoff, MD
roles:
Co-Investigator
affiliations:
United States Department of Health and Human Services, Washington, DC, USA
name:
P01 CA109552
roles:
Funding Source
performedBy:
TitleNameInstitute Principal InvestigatorWinnie S. Liang, PhDTranslational Genomics Research Institute, Phoenix, AZ, USA Co-InvestigatorDavid W. Craig, PhDTranslational Genomics Research Institute, Phoenix, AZ, USA Co-InvestigatorJohn Carpten, PhDTranslational Genomics Research Institute, Phoenix, AZ, USA Co-InvestigatorMitesh J. Borad, MDTranslational Genomics Research Institute, Phoenix, AZ, USA Co-InvestigatorDaniel Von Hoff, MDTranslational Genomics Research Institute, Phoenix, AZ, USA
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000550.v1.p1
Identifier:
phs000550.v1.p1_policy
name:
Data Use Certificate
Identifier:
1
name:
General Research Use
schedulesActivity:
This study was carried out using samples collected between 2010 and 2011. The research was performed between 2010 and 2012.
alternateIdentifiers:
yes
selectionCriteria:

Inclusion criteria: patients had to be ≥ 18 years of age and provided signed informed consent. These patients included those with a pathologic or clinical diagnosis of a pancreatic malignant neoplasm, or who were undergoing a medically indicated procedure to obtain tissue or to resect their pancreatic tumor. Other eligibility criteria included: Karnofsky performance status (PS) ≥ 80%, life expectancy > 3 months, baseline laboratory data indicating acceptable bone marrow reserve, liver, and renal function.

types:
Case Set
dateReleased:
09-28-2012
version:
phs000550.v1.p1
dateModified:
01-24-2013
abbreviation:
NCI
name:
NCI
ID:
0
name:
dbGaP

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