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Title: Pancreatic Cancer Cohort and Case-Control Consortium (PanScan)      
citations:
20101243
25086665
19648918
description:
Within the framework of the NCI-sponsored Cohort Consortium, investigators from 12 prospective epidemiologic cohorts formed the Pancreatic Cancer Cohort Consortium in 2006. This study, also known as "PanScan", is funded by the National Cancer Institute (NCI) and involves conducting a genome-wide association study (GWAS) of common genetic variants to identify markers of susceptibility to pancreatic cancer. In 2007, the study was expanded to include 8 case-control studies. The study team includes scientists from the cohorts comprising the Consortium, the NCI and the Pancreatic Cancer Case Control Consortium (PanC4). PanScan I and II were conducted in 12 cohort studies and 8 case-control studies, leading to the discovery of four novel regions in the genome associated with risk for pancreatic adenocarcinoma. The third phase of PanScan (PanScan III) was conducted using recently identified incident pancreatic cancer cases drawn from fourteen cohorts from the cohort consortium, including nine prospective cohorts who participated in PanScan I, and five newly joined cohorts. The nine cohort studies that participated in PanScan I and had new genotyping of cases in PanScan III include ATBC, CPS-II, EPIC, HPFS, NHS, PHS, PLCO, SMWHS, and WHI; the five newly joined cohort studies include the Agricultural Health Study (AHS), the Multiethnic Cohort Study (MEC), the Melbourne Collaborative Cohort Study (MCCS), the Vitamins and Lifestyle Study (VITAL), and Selenium and Vitamin E Cancer Prevention Trial (SELECT). In addition to the cases from cohorts, we also included cases from the Gastrointestinal Cancer Clinic of Dana-Farber Cancer Institute Study (DFCI-GCC); from the University Hospital in Heidelberg, Germany, which is part of a larger European clinical case-control study (PANDoRA); and from clinic-based cases from eastern Spain (PANKRAS-II). The dbGaP datasets available include all subjects previously made available from PanScan I and II (phs000206.v4.p3), plus 1,582 new incident pancreatic cancer cases of European descent from prospective cohorts, case-control studies or case series (genotyped as part of PanScan III). Also included are 61 pancreatic cancer cases and 67 control subjects from PanScan I as well as 173 pancreatic cancer cases from PanScan III of Asian ancestry from the Shanghai Men's and Women's Health Study (Supplemental Table 10, Wolpin et al. (Nat Genet, 2014)). The control population used in the analysis for the Wolpin et al. manuscript included cancer-free individuals from the prospective cohorts that contributed pancreatic cancer cases to PanScan III and controls from the Spanish Bladder Cancer SBC/EPICURO study that were previously genotyped using the OmniExpress, Omni 1M or Omni 2.5M SNP arrays. The data from these control subjects were posted to dbGaP under the GWAS in which they were initially genotyped and will not be made available in duplicate under this dbGaP study.
Identifier:
phs000206.v5.p3
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000206.v5.p3
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Pancreatic Neoplasms
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Laufey Amundadottir
roles:
Principal Investigator
affiliations:
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
name:
Brian Wolpin
roles:
Principal Investigator
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Rachael Stolzenberg-Solomon
roles:
Principal Investigator
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Laura Beane-Freeman
roles:
Study Representatives
affiliations:
Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain
name:
Nuria Malats
roles:
Study Representatives
affiliations:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
name:
Kala Visvanathan
roles:
Study Representatives
affiliations:
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA
name:
Eric Jacobs
roles:
Study Representatives
affiliations:
Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
name:
Eric Duell
roles:
Study Representatives
affiliations:
Department of Medical Oncology, Dana-Farber Cancer Institute and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
name:
Charlie Fuchs
roles:
Study Representatives
affiliations:
The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA
name:
Larry Kolonel
roles:
Study Representatives
affiliations:
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
name:
Graham Giles
roles:
Study Representatives
affiliations:
Department of Obstetrics and Gynecology, Department of Environmental Medicine, New York University School of Medicine and New York University Cancer Institute, New York, NY, USA
name:
Alan Arslan
roles:
Study Representatives
affiliations:
Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA
name:
Myron Gross
roles:
Study Representatives
affiliations:
Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
name:
Wei Zheng
roles:
Study Representatives
affiliations:
Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
name:
Phyllis Goodman
roles:
Study Representatives
affiliations:
Fred Hutchinson Cancer Research Center, Seattle, Washington, Department of Epidemiology, University of Washington, Seattle, Washington, USA
name:
Emily White
roles:
Study Representatives
affiliations:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
name:
Charles Kooperberg
roles:
Study Representatives
affiliations:
Department of Epidemiology, University of Washington, Seattle, Washington, USA
name:
Melissa A Austin
roles:
Study Representatives
affiliations:
Department of Oncology, Pathology and Epidemiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
name:
Allison Klein
roles:
Study Representatives
affiliations:
Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
name:
Gloria Petersen
roles:
Study Representatives
affiliations:
Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
name:
Donghui Li
roles:
Study Representatives
affiliations:
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
name:
Sara Olson
roles:
Study Representatives
affiliations:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
name:
Steve Gallinger
roles:
Study Representatives
affiliations:
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
name:
Paige Bracci
roles:
Study Representatives
affiliations:
Yale University School of Public Health, New Haven, CT, USA
name:
Harvey Risch
roles:
Study Representatives
affiliations:
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:
Federico Canzian
roles:
Study Representatives
affiliations:
Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA
name:
Kouros Owzar
roles:
Study Representatives
affiliations:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
name:
Gary Goodman
roles:
Study Representatives
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Kai Yu
roles:
Statistician
affiliations:
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
name:
Peter Kraft
roles:
Statistician
affiliations:
Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
name:
Zhaoming Wang
roles:
Bioinformatics
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Patricia Hartge
roles:
Coordination
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Robert Hoover
roles:
Coordination
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Stephen Chanock
roles:
Coordination
affiliations:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Geoffrey Tobias
roles:
Coordination
affiliations:
Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA
name:
Joanne Elena
roles:
Coordination
affiliations:
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
name:
HHSN261200800001E
roles:
Funding Source
affiliations:
the American Society of Clinical Oncology Conquer Cancer Foundation, the Howard Hughes Medical Institute, the Lustgarten Foundation, the Robert T. and Judith B. Hale Fund for Pancreatic Cancer Research and Promises for Purple to B.M.W.
name:
NIH/NCI K07 CA140790
roles:
Funding Source
performedBy:
TitleNameInstitute Principal InvestigatorLaufey AmundadottirDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA Principal InvestigatorBrian WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA Principal InvestigatorRachael Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA Study RepresentativesLaura Beane-FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA Study RepresentativesNuria MalatsGenetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000206.v5.p3
Identifier:
phs000206.v5.p3_policy
name:
Data Use Certificate
Identifier:
1
name:
Cancer in all age groups, other diseases in adults only, and methods
Identifier:
2
name:
Disease-Specific (Pancreatic Cancer, GSO)
Identifier:
4
name:
Disease-Specific (Pancreatic Cancer, IRB, COL, GSO)
Identifier:
5
name:
General Research Use
Identifier:
6
name:
Health/Medical/Biomedical (PUB, NPU, MDS, GSO)
schedulesActivity:
The Pancreatic Cancer Cohort Consortium Each of the 17 member studies of the Cohort Consortium participating in this GWAS is a prospective study of a defined population with blood or buccal cells collected prior to the occurrence of pancreatic cancer. Study characteristics vary but the common and standard prospective cohort design allows for rigorous pooled analysis. Additional information can be found at http://epi.grants.cancer.gov/Consortia/cohort.html/. The studies included in PanScan from the Pancreatic Cancer Cohort Consortium are: ACS Cancer Prevention Study-II (CPS II) Agricultural Health Study (AHS) Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (ATBC) European Prospective Investigation into Cancer and Nutrition Study (EPIC) Give Us a Clue to Cancer and Heart Disease Study (Clue II) Health Professional's Follow-up Study (HPFS) The Melbourne Collaborative Cohort Study (MCCS) Multiethnic Cohort Study of Diet and Health (MEC) NYU Women's Health Study (NYUWHS) Nurses' Health Study (NHS) Physicians' Health Study (PHS) Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial Selenium and Vitamin E Cancer Prevention Trial (SELECT) Shanghai Men's and Women's Health Study (SMWHS) Vitamins and Lifestyle Study (VITAL) Women's Health Initiative (WHI) Women's Health Study (WHS) Ten case-control studies and one case series participating in this GWAS with blood or buccal cells collected from individuals with pancreatic cancer or healthy controls. Eight studies are part of the Pancreatic Cancer Case Control Consortium (PanC4). The PanC4 case-control consortium consists of a group of scientists from diverse biomedical disciplines (Epidemiology, Genetics, Biostatistics, Bioinformatics, Molecular Biology, Gastroenterology, Surgery) across the world who have joined together to improve understanding of the causes of pancreatic cancer through joint, or pooled analyses of our data. Additional information can be found at www.panc4.org. The studies included in PanScan (PanScan II) from PanC4 are: PACIFIC Study of Group Health and Northern California Kaiser Permanente Johns Hopkins University Mayo Clinic SPORE in Pancreatic Cancer MD Anderson Cancer Center Memorial Sloan Kettering Cancer Center University of California San Francisco University of Toronto Yale University Three additional case-control studies or case-series were included in PanScan (PanScan III): Gastrointestinal Cancer Clinic of Dana-Farber Cancer Institute Study (DFCI-GCC) University Hospital in Heidelberg, Germany (part of the PANcreatic Disease ReseArch (PANDoRA) consortium) PANKRAS-II
alternateIdentifiers:
yes
selectionCriteria:

Cases were defined as those individuals having primary adenocarcinoma of the exocrine pancreas (ICD-O-3 code C250-C259). Those with non-exocrine pancreatic tumors (histology types 8150, 8151, 8153, 8155 and 8240) were excluded.

dateReleased:
07-10-2015
version:
phs000206.v5.p3
dateModified:
07-23-2015
Identifier:
2874
Name:
Logistic Regression
Identifier:
2889
Name:
categorical analysis on single SNP
abbreviation:
NCI
name:
NCI
ID:
0
name:
dbGaP