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Title: Geisinger eMERGE - Abdominal Aortic Aneurysm Project (AAAP)      
citations:
19497516
20622881
21493888
19783185
20446064
21146954
description:
A large research cohort of Geisinger Abdominal Aortic Aneurysm (AAA) patients was created by enrolling and consenting patients of the Geisinger Department of Vascular Surgery. Consented patients provide blood, serum and DNA samples for research and authorize use of data in their medical record for research. They also complete a data questionnaire that asks information about family history of AAA and other vascular diseases, as well as information on known or suspected AAA risk factors, including smoking history, body mass index, hypertension, type 2 diabetes, and atherosclerotic disease. The AAA cases are 78% male, with a mean age of 74 years; 39% have undergone surgical or endovascular repair; more than 85% or current or past smokers; approximately 20% of cases report a positive family history of AAA. Geisinger AAA patients undergo regular imaging studies, typically every 6 months, to monitor the progression of aneurysm expansion. This allows the growth rates of their aneurysm to be calculated. DNA samples from a total of 910 AAA patients were used for whole genome genotyping; these results are included in the dbGaP.
Identifier:
phs000387.v1.p1
accesstypes:
download
enclave
landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000387.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Abdominal Aortic Aneurysms
affiliations:
Weis Center for Research, Geisinger Clinic, Danville, PA, USA
name:
David Carey, PhD
roles:
Principal Investigator
affiliations:
Department of Vascular Surgery, Geisinger Clinic, Danville, PA, USA
name:
James Elmore, MD
roles:
Co-Investigators
affiliations:
Weis Center for Research, Geisinger Clinic, Danville, PA, USA
name:
Helena Kuivaniemi, MD, PhD
roles:
Co-Investigators
affiliations:
Weis Center for Research, Geisinger Clinic, Danville, PA, USA
name:
Gerard Tromp, PhD
roles:
Co-Investigators
affiliations:
Weis Center for Research, Geisinger Clinic, Danville, PA, USA
name:
Glenn Gerhard, MD
roles:
Co-Investigators
affiliations:
Department of Vascular Surgery, Geisinger Clinic, Danville, PA, USA
name:
David Franklin, MD
roles:
Co-Investigators
affiliations:
Geisinger Clinic, Danville, PA, USA
name:
Geisinger Clinic
roles:
Funding Source for Genotyping
affiliations:
Genomics and Proteomics Core Laboratories, University of Pittsburgh, Pittsburgh, PA, USA
name:
Deborah J. Hollingshead, PhD
roles:
Genotyping Center
performedBy:
TitleNameInstitute Principal InvestigatorDavid Carey, PhDWeis Center for Research, Geisinger Clinic, Danville, PA, USA Co-InvestigatorsJames Elmore, MDDepartment of Vascular Surgery, Geisinger Clinic, Danville, PA, USA Co-InvestigatorsHelena Kuivaniemi, MD, PhDWeis Center for Research, Geisinger Clinic, Danville, PA, USA Co-InvestigatorsGerard Tromp, PhDWeis Center for Research, Geisinger Clinic, Danville, PA, USA Co-InvestigatorsGlenn Gerhard, MDWeis Center for Research, Geisinger Clinic, Danville, PA, USA
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000387.v1.p1
Identifier:
phs000387.v1.p1_policy
name:
Data Use Certificate
Identifier:
1
name:
Health Research - Geisinger Clinic - AAA
alternateIdentifiers:
yes
selectionCriteria:

Inclusion criteria: An individual was eligible for participation in this study if they were an adult meeting the following criteria: 1) Is a Geisinger Clinic patient; 2) Consented to participate in the Geisinger AAA biobanking project (these include condition-specific criteria, e.g. patient meeting clinical criteria for abdominal aortic aneurysm); and 3) the consent for the Geisinger biobanking project included linking the samples to the subject's electronic health information and was broad enough to allow genetic association studies.

Exclusion criteria: Dementia that precludes informed consent.

types:
Case Set
dateReleased:
08-03-2011
version:
phs000387.v1.p1
dateModified:
12-16-2011
abbreviation:
NHGRI
name:
National Human Genome Research Institute
ID:
0
name:
dbGaP

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