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Title: Genome Wide Association for Asthma and Lung Function      
citations:
21804549
description:
The SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic (STAMPEED) asthma project includes subjects with asthma and controls from the Chicago Asthma Genetics Study (CAG), NHLBI multicenter Severe Asthma Research Program (SARP) and NHLBI Collaborative Studies on the Genetics of Asthma CSGA (Wake Forest). All studies included European American and African American children and adults with asthma ranging from mild to severe and adult controls. CAG participants were collected at the University of Chicago. SARP participants were recruited at the NHLBI SARP sites with an emphasis on recruiting severe asthmatics (Moore et al, Am J Respir Crit Care Med, 2010, PMID: 19892860). CSGA cases and controls collected by the Wake Forest investigators were also included. Asthma status was based on both a physician's diagnosis and either bronchodilator reversibility or hyper-responsiveness to methacholine as well as less than 5 pack years of smoking. Genotyping was performed on the Illumina 1Mv1 platform, with individual genotypes called using clustering algorithms as implemented in the BeadStudio software by Illumina. The total number of markers following standard QC was 1,025,129. Imputation was performed using the HapMap phase 2, release 21 SNPs using MACH with the phased HapMap CEU and YRI haplotypes as a reference. Case/control association tests for asthma status were performed using logistic regression in R (http://CRAN.R-project.org/) on genotype dosages, and adjusting for the first principal component from EIGENSTRAT.
Identifier:
phs000355.v1.p1
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000355.v1.p1
authentication: simpleLogin
none
authorization:
none
duaIndividual
name:
Asthma
Respiratory Function Tests
affiliations:
Wake Forest School of Medicine, Winston-Salem, NC, USA
name:
Deborah A. Meyers, PhD
roles:
Principal Investigator
affiliations:
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
name:
R01 HL087665
roles:
Funding Source
performedBy:
TitleNameInstitute Principal InvestigatorDeborah A. Meyers, PhDWake Forest School of Medicine, Winston-Salem, NC, USA Funding SourceR01 HL087665National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
downloadURL: https://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&view_pdf&stacc=phs000355.v1.p1
Identifier:
phs000355.v1.p1_policy
name:
Data Use Certificate
Identifier:
100
name:
Analysis only
schedulesActivity:
This is part of NHLBI's STAMPEED program (RFA-HL-06-012).
alternateIdentifiers:
no
selectionCriteria:

Cases with asthma were excluded if they did not meet inclusion criteria or had a diagnosis of a respiratory disease besides asthma. Controls were excluded if they had a history of asthma.

types:
Case-Control
dateReleased:
04-04-2011
version:
phs000355.v1.p1
dateModified:
10-26-2011
Identifier:
3127
Name:
categorical analysis
Identifier:
3128
Name:
categorical analysis
abbreviation:
NHLBI
name:
National Heart, Lung, and Blood Institute DAC
ID:
0
name:
dbGaP