<< Go Back

Metadata

Name
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
Repository
ClinicalTrials.gov
Identifier
clinicaltrials:NCT01269723
Description
Vegetables such as broccoli, cauliflower, kale and cabbage are particularly rich in a plant
chemical called sulforaphane (SFN) which boosts production of certain "defense" enzymes that
increase the activity of antioxidants. In animals, the chemical protection from SFN helps
prevent diseases associated with inflammation and cancer among others, and this is currently
being studied in humans.

Young broccoli sprouts have a particularly high level of SFN compared to other foods. The
purpose of this research study is to learn about short term responses to live attenuated
influenza virus (LAIV, administered to you via Flumist® vaccine) between smoking and
nonsmoking volunteers treated with broccoli sprout homogenates ("shake") or a placebo
homogenate. This will be done by obtaining a series of "nasal lavages" or rinses of your nose
with salt water, as well as 3 superficial biopsies of the inside lining of your nose both
before and after you receive the vaccine. Using these samples, we will measure the amount of
virus and the amount of inflammation in your nose and compare how smokers and nonsmokers
respond to the vaccine when they are given a broccoli sprout homogenate (high in SFN) or a
placebo alfalfa spout "shake" which is low in SFN during each of 4 study visits.

Subjects will be seen for a screening visit (inc. HIV test) and then randomly assigned to
receive 1 of 2 homogenates. Broccoli sprout homogenate will be the the active treatment arm
while the placebo arm will be alfalfa sprout homogenate. Two to 4 weeks after screening,
subjects will return for 5 sequential visits (Monday-Friday). Monday-Thursday they will
receive the assigned homogenate. On Tuesday, they will receive the Flumist®vaccine. Subjects
will also be seen at 1 and 3 weeks post vaccine. Nasal lavage (NL), blood samples and nasal
biopsies will performed prior to and after study interventions.
Data or Study Types
clinical trial
Keywords
influenza, Smoking, influenza vaccine
Source Organization
Unknown
Access Conditions
available
Year
2010
Access Hyperlink
https://clinicaltrials.gov/ct2/show/NCT01269723

Distributions