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Metadata

Name
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Repository
ClinicalTrials.gov
Identifier
clinicaltrials:NCT04959825
Description
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many
functions in the body but it is mostly known for maintaining a circadian rhythm that is
governed by the central circadian pacemaker (biological clock) in the suprachiasmatic nuclei
in the hypothalamus. Melatonin works by attaching to receptors or nerve endings in the
suprachiasmatic nucleus (SCN) in the hypothalamus. It binds to melatonin receptor 1 and
melatonin receptor 2, commonly referred to as MT1 and MT2. People can take it as a natural or
synthetic supplement to promote restful sleep. Melatonin showed promise for preventing shifts
in sleep and wake times in people with jetlag and improving sleep in people with insomnia. It
can also be used for headaches, cancer, and Alzheimer's disease.

Melatonin can be used as an analgesic, sedative, and hypnotic drug that can distinguish it as
an attractive alternative premedicant
Data or Study Types
clinical trial
Source Organization
Unknown
Access Conditions
available
Year
2021
Access Hyperlink
https://clinicaltrials.gov/ct2/show/NCT04959825

Distributions

  • Encoding Format: HTML ; URL: https://clinicaltrials.gov/ct2/show/results/NCT04959825
melatoninpeoplesleepcircadianreceptorusedhormonepinealglandbrainproducescentralclocknucleiscn
This project was funded in part by grant U24AI117966 from the NIH National Institute of Allergy and Infectious Diseases as part of the Big Data to Knowledge program. We thank all members of the bioCADDIE community for their valuable input on the overall project.