Metadata
- Name
- DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
- Repository
- HGVS Locus Specific Mutation Databases
- Identifier
- doi:603503
- Description
- The DPM1 gene encodes the cytoplasmic catalytic subunit of dolichol-phosphate-mannose synthase ({EC 2.4.1.83}), an enzyme complex that synthesizes dolichol-phosphate-mannose (Dol-P-Man) from GDP-mannose and dolichol-phosphate. DPM2 ({603564}) and DPM3 ({605951}) are integral endoplasmic reticulum membrane proteins that stabilize the complex. Dol-P-Man serves as a donor of mannosyl residues in various eukaryotic glycosylation processes, including N-glycosylation of asparagine residues and O-mannosylation of alpha-dystroglycan (DAG1; {128239}) (summary by {4:Garcia-Silva et al., 2004} and {9:Yang et al., 2013}).
- Data or Study Types
- gene expression
- Source Organization
- Human Genome Variation Society
- Access Conditions
- available
- Year
- 2018