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Metadata

Name
Commensal microbiota constantly control maturation and function of microglia in the central nervous system
Repository
Gemma
Identifier
gemma.experiment:12557
Description
As tissue macrophages of the central nervous system (CNS), microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. Here we reveal significant contributions of the host microbiota to microglia homeostasis as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype leading to impaired innate immune responses. Temporal eradication of host microbiota severely changed microglia properties. Limited microbiota complexity also resulted in defective microglia. In contrast, recolonization with a complex microbiota partially restored microglia features. We determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulate microglia homeostasis. Accordingly, mice deficient for the SCFA receptor FFAR2 mirrored microglia defects found under GF conditions. These findings reveal that host bacteria vitally regulate microglia maturation and function, whereas microglia impairment can be restored to some extent by complex microbiota.
Last Updated (by provider): May 29 2018
Contributors: Anna L Hrab? de Angelis Eunyoung Chun Daniel Erny Thorsten Buch Peter Staeheli Andreas Diefenbach Kristin Jacobshagen Marco Prinz Olaf Utermöhlen Peter Wieghofer Eyal David Hadas Keren-Shaul Bärbel Stecher Wendy S Garrett Diego A Jaitin Vera Schwierzeck Ido Amit Ori Staszewski Tanel Mahlakoiv Kathy D McCoy
Data or Study Types
gene expression
Keywords
functional genomics
Source Organization
University of British Columbia
Access Conditions
available
Access Hyperlink
www.chibi.ubc.ca/Gemma/expressionExperiment/showExpressionExperiment.html?id=12557

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