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Title: Changes in brain anatomy during the course of PTSD      
dateReleased:
12-19-2016
privacy:
information not avaiable
aggregation:
instance of dataset
dateCreated:
10-11-2012
refinement:
curated
ID:
doi:10.7272/Q6RN35SZ
creators:
Cardenas, Valerie
Samuelson, Kristin
Lenoci, Maryanne A.
Studholme, Colin
Neylan, Thomas C.
Marmar, Charles R.
Schuff, Norbert
Weiner, Michael W.
availability:
available
types:
other
description:
Longitudinal structural T1-weighted images from middle-aged controls and veterans with PTSD (post-traumatic stress disorder). Most patients were Vietnam veterans. The goal of this study was to determine whether PTSD was associated with an increase in time-related decline in macrostructural brain volume and whether these changes were associated with accelerated cognitive decline. To quantify brain structure, 3 dimensional T1-weighted MRI scans were performed at baseline and again after a minimum of 24 months in 25 patients with PTSD and 22 controls. Longitudinal changes in brain volume were measured using deformation morphometry. For the group as a whole PTSD+ patients did not show significant ongoing brain atrophy compared to PTSD-. PTSD+ patients were then subgrouped into those with decreasing or increasing symptoms. We found little evidence for brain markers of accelerated atrophy in PTSD+ veterans whose symptoms improved over time, with only a small left parietal region showing greater ongoing tissue loss than PTSD-. PTSD patients whose symptoms increased over time showed accelerated atrophy throughout the brain, particularly brainstem and frontal and temporal lobes. Lastly, for the sample as a whole greater rates of brain atrophy were associated with greater rates of decline in verbal memory and delayed facial recognition.
accessURL: https://doi.org/10.7272/Q6RN35SZ
storedIn:
University of California, San Francisco
qualifier:
not compressed
format:
HTML
accessType:
landing page
authentication:
none
authorization:
none
abbreviation:
UCSF
homePage: http://www.ucsf.edu/
ID:
SCR:010605
name:
University of California at San Francisco
abbreviation:
UCSF-CTSI
homePage: https://ctsi.ucsf.edu/
ID:
SCR:014711
name:
UCSF Clinical & Translational Science Institute