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Title: Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space      
dateReleased:
02-07-2017
description:
In neurosurgical literature, findings such as deep brain stimulation (DBS) electrode positions are conventionally reported in relation to the anterior and posterior commissures of the individual patient (AC/PC coordinates). However, the neuroimaging literature including neuroanatomical atlases, activation patterns, and brain connectivity maps has converged on a different population-based standard (MNI coordinates). Ideally, one could relate these two literatures by directly transforming MRIs from neurosurgical patients into MNI space. However obtaining these patient MRIs can prove difficult or impossible, especially for older studies or those with hundreds of patients. Here, we introduce a methodology for mapping an AC/PC coordinate (such as a DBS electrode position) to MNI space without the need for MRI scans from the patients themselves. We validate our approach using a cohort of DBS patients in which MRIs are available, and test whether several variations on our approach provide added benefit. We then use our approach to convert previously reported DBS electrode coordinates from eight different neurological and psychiatric diseases into MNI space. Finally, we demonstrate the value of such a conversion using the DBS target for essential tremor as an example, relating the site of the active DBS contact to different MNI atlases as well as anatomical and functional connectomes in MNI space.
privacy:
information not available
aggregation:
instance of dataset
availability:
available
refinement:
analyzed data
dateModified:
02-07-2017
creators:
andreashorn
ID:
2200
types:
image
name:
Homo sapiens
ID:
doi:10.1016/j.neuroimage.2017.02.004
authors:
Andreas Horn
Andrea A. Kühn
Angela Merkl
Ludy Shih
Ron Alterman
Michael Fox
method:
magnetic resonance imaging
accessURL: http://neurovault.org/collections/2200/download
storedIn:
NeuroVault
qualifier:
gzip compressed
license:
CC0 license
format:
NIfTI
accessType:
download
authentication:
none
authorization:
none
abbreviation:
NeuroVault
homePage: http://neurovault.org/
ID:
SCR:003806
name:
NeuroVault
abbreviation:
NeuroVault
homePage: http://neurovault.org/
ID:
SCR:003806
name:
NeuroVault
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