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Title: NEF_HV1Z6      
types:
sequence
dateReleased:
01-23-2007
privacy:
not applicable
availability:
available
version:
3
creators:
Srinivasan A.
Anand R.
York D.
Ranganathan P.
Feorino P.
Schochetman G.
Curran J.
Kalyanaraman V.S.
Luciw P.A.
Sanchez-Pescador R.
ID:
P04602
keywords:
3D-structure
AIDS
Apoptosis
Early protein
Host cell membrane
Host Golgi apparatus
Host membrane
Host-virus interaction
Inhibition of host adaptive immune response by virus
Inhibition of host autophagy by virus
Inhibition of host MHC class I molecule presentation by virus
Inhibition of host MHC class II molecule presentation by virus
Lipoprotein
Membrane
Myristate
Phosphoprotein
Secreted
SH3-binding
Viral immunoevasion
Virion
Virulence
refinement:
curated
aggregation:
instance of dataset
description:
Removed; by host Protein Nef C-terminal core protein Acidic; interacts with host PACS1 and PACS2; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization SH3-binding; interaction with Src family tyrosine kinases Mediates dimerization, Nef-PTE1 interaction, Nef-induced CD4 and MHC-I down-regulation and enhancement of infectivity Binding to ATP6V1H PxxP; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization Dileucine internalization motif; necessary for CD4 internalization Diacidic; necessary for CD4 internalization Cleavage; by viral protease Phosphoserine; by host N-myristoyl glycine; by host
name:
Human immunodeficiency virus type 1 group M subtype D
strain:
isolate Z6
ID:
ncbitax:11708
year:
1987
authorsList:
Srinivasan A.
Anand R.
York D.
Ranganathan P.
Feorino P.
Schochetman G.
Curran J.
Kalyanaraman V.S.
Luciw P.A.
Sanchez-Pescador R.
type:
PubMed
DOI
ID: pmid:3036660
doi:10.1016/0378-1119(87)90396-9
name:
Protein Nef
name:
nef
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P04602
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P04602.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

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