NACHT, LRR and PYD domains-containing protein 1b allele 1 NACHT LRR 1 LRR 2 CARD ATP FIIND Probable cleavage; by anthrax lethal toxin (LT) endopeptidase component Cleavage; by autocatalysis Low spontaneous IL1B release and loss of activation by LT. Increased IL1B release in response to metabolic inhibitors Low spontaneous IL1B release and loss of activation by LT. No effect on activation by metabolic inhibitors No effect on IL1B release No effect on cleavage by LT, nor on IL1B processing. No effect on cleavage by LT, nor on IL1B processing; when associated with 38-A-A-39 No effect on cleavage by LT No effect on cleavage by LT, nor on IL1B processing Loss of cleavage by LT and of LT-induced IL1B processing and suppression of LT-induced pyroptosis in macrophages, no effect on IL1B release in response to metabolic inhibitors; when associated with A-44 and Q-45 Partial loss of cleavage by LT and of LT-induced IL1B processing. Loss of cleavage by LT and of LT-induced IL1B processing; when associated with Q-43 and Q-45. No effect on IL1B release in response to metabolic inhibitors; when associated with Q-43 and Q-45 Loss of cleavage by LT and of LT-induced IL1B processing. Loss of cleavage by LT and of LT-induced IL1B processing; when associated with Q-43 and A-44. No effect on IL1B release in response to metabolic inhibitors; when associated with Q-43 and A-44 Constitutive IL1B release Constitutive IL1B processing Increased IL1B release under basal conditions. No effect on IL1B release in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-634 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-632 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-659 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-658 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors, no effect on the response to LT; when associated with A-664 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors, no effect on the response to LT; when associated with A-663 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, no effect on the response to metabolic inhibitors, partial loss of response to LT; when associated with A-687 Spontaneous IL1B release under basal conditions, no effect on the response to metabolic inhibitors, partial loss of response to LT; when associated with A-686 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Low spontaneous IL1B release, no effect on the response to metabolic inhibitors, nor to LT No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-701 and A-702 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-698 and A-702 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-698 and A-701 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Increased IL1B release under basal conditions. No effect on IL1B release in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-738 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-734 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-746 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-744 No effect on response to LT, attenuated response to metabolic inhibitors No effect on response to LT, attenuated response to metabolic inhibitors Loss of autocatalytic cleavage within the FIIND region. No effect on cleavage by LT Loss of autocatalytic cleavage within the FIIND region and of IL1B release, decrease in CASP1-binding. No effect on homomerization Strong decrease of IL1B release, but no effect on autocatalytic cleavage within the FIIND region No effect on autocatalytic cleavage within the FIIND region No effect on autocatalytic cleavage within the FIIND region Decrease of IL1B release, but no effect on autocatalytic cleavage within the FIIND region Loss of homomerization, of autocatalytic cleavage within the FIIND region and of IL1B release. No effect on CASP1-binding No effect on autocatalytic cleavage within the FIIND region

sequence

02-21-2006

Q2LKW6

not applicable

ATP-binding

Cytoplasm

Immunity

Inflammasome

Inflammatory response

Innate immunity

Leucine-rich repeat

Membrane

Nucleotide-binding

Repeat

available

curated

1

instance of dataset

Mus musculus

Mouse

ncbitax:10090

NACHT, LRR and PYD domains-containing protein 1b allele 1

none

none

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UniProt

landing page

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Creative Commons Attribution-NoDerivs License

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FASTA

UniProt

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Creative Commons Attribution-NoDerivs License

European Bioinformatics Institute

EMBL-EBI

SCR:004727

UniProt

UniProt

SCR:002380