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Title: NL1B1_MOUSE      
description:
NACHT, LRR and PYD domains-containing protein 1b allele 1 NACHT LRR 1 LRR 2 CARD ATP FIIND Probable cleavage; by anthrax lethal toxin (LT) endopeptidase component Cleavage; by autocatalysis Low spontaneous IL1B release and loss of activation by LT. Increased IL1B release in response to metabolic inhibitors Low spontaneous IL1B release and loss of activation by LT. No effect on activation by metabolic inhibitors No effect on IL1B release No effect on cleavage by LT, nor on IL1B processing. No effect on cleavage by LT, nor on IL1B processing; when associated with 38-A-A-39 No effect on cleavage by LT No effect on cleavage by LT, nor on IL1B processing Loss of cleavage by LT and of LT-induced IL1B processing and suppression of LT-induced pyroptosis in macrophages, no effect on IL1B release in response to metabolic inhibitors; when associated with A-44 and Q-45 Partial loss of cleavage by LT and of LT-induced IL1B processing. Loss of cleavage by LT and of LT-induced IL1B processing; when associated with Q-43 and Q-45. No effect on IL1B release in response to metabolic inhibitors; when associated with Q-43 and Q-45 Loss of cleavage by LT and of LT-induced IL1B processing. Loss of cleavage by LT and of LT-induced IL1B processing; when associated with Q-43 and A-44. No effect on IL1B release in response to metabolic inhibitors; when associated with Q-43 and A-44 Constitutive IL1B release Constitutive IL1B processing Increased IL1B release under basal conditions. No effect on IL1B release in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-634 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-632 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-659 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-658 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors, no effect on the response to LT; when associated with A-664 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors, no effect on the response to LT; when associated with A-663 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, no effect on the response to metabolic inhibitors, partial loss of response to LT; when associated with A-687 Spontaneous IL1B release under basal conditions, no effect on the response to metabolic inhibitors, partial loss of response to LT; when associated with A-686 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Low spontaneous IL1B release, no effect on the response to metabolic inhibitors, nor to LT No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-701 and A-702 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-698 and A-702 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-698 and A-701 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors Increased IL1B release under basal conditions. No effect on IL1B release in response to LT or metabolic inhibitors No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-738 No effect on IL1B release under basal conditions, nor in response to LT or metabolic inhibitors; when associated with A-734 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-746 Spontaneous IL1B release under basal conditions, loss of response to metabolic inhibitors and to LT; when associated with A-744 No effect on response to LT, attenuated response to metabolic inhibitors No effect on response to LT, attenuated response to metabolic inhibitors Loss of autocatalytic cleavage within the FIIND region. No effect on cleavage by LT Loss of autocatalytic cleavage within the FIIND region and of IL1B release, decrease in CASP1-binding. No effect on homomerization Strong decrease of IL1B release, but no effect on autocatalytic cleavage within the FIIND region No effect on autocatalytic cleavage within the FIIND region No effect on autocatalytic cleavage within the FIIND region Decrease of IL1B release, but no effect on autocatalytic cleavage within the FIIND region Loss of homomerization, of autocatalytic cleavage within the FIIND region and of IL1B release. No effect on CASP1-binding No effect on autocatalytic cleavage within the FIIND region
types:
sequence
dateReleased:
02-21-2006
ID:
Q2LKW6
privacy:
not applicable
keywords:
ATP-binding
Cytoplasm
Immunity
Inflammasome
Inflammatory response
Innate immunity
Leucine-rich repeat
Membrane
Nucleotide-binding
Repeat
availability:
available
refinement:
curated
version:
1
aggregation:
instance of dataset
name:
Mus musculus
strain:
Mouse
ID:
ncbitax:10090
name:
NACHT, LRR and PYD domains-containing protein 1b allele 1
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/Q2LKW6
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/Q2LKW6.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

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