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Title: KGX21_MESEU      
description:
Potassium channel toxin gamma-KTx 2.1 Crucial for Kv11/ERG channel binding, plugs its side chain into the channel selectivity filter Crucial for Kv11/ERG channel binding 6.7-fold decrease in affinity to Kv11/ERG potassium channels 1.7-fold decrease in affinity to Kv11/ERG potassium channels 3.4-fold decrease in affinity to Kv11/ERG potassium channels 2.7-fold decrease in affinity to Kv11/ERG potassium channels 0.8-fold decrease in affinity to Kv11/ERG potassium channels 14.7-fold decrease in affinity to Kv11/ERG potassium channels 2.3-fold decrease in affinity to Kv11/ERG potassium channels 8.2-fold decrease in affinity to Kv11/ERG potassium channels 86.4-fold decrease in affinity to Kv11/ERG potassium channels 70.6-fold decrease in affinity to Kv11/ERG potassium channels 52.2-fold decrease in affinity to Kv11/ERG potassium channels 14.6-fold decrease in affinity to Kv11/ERG potassium channels 7.4-fold decrease in affinity to Kv11/ERG potassium channels 60% loss of toxicity. No loss of activity; when associated with K-53 1.2-fold decrease in affinity to ERG-potassium channels 1.4-fold decrease in affinity to ERG-potassium channels No loss of activity. No loss of activity but gain in inhibition of native calcium- activated potassium channels with Kd of about 72 nM; when associated with K-48 1.1-fold decrease in affinity to Kv11/ERG potassium channels 3.2-fold decrease in affinity to Kv11/ERG potassium channels
types:
sequence
dateReleased:
06-01-2001
ID:
Q9BKB7
privacy:
not applicable
keywords:
3D-structure
Direct protein sequencing
Disulfide bond
Ion channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Secreted
Signal
Toxin
Voltage-gated potassium channel impairing toxin
availability:
available
refinement:
curated
version:
1
aggregation:
instance of dataset
name:
Mesobuthus eupeus
strain:
Lesser Asian scorpion
ID:
ncbitax:34648
name:
Potassium channel toxin gamma-KTx 2.1
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/Q9BKB7
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/Q9BKB7.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

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