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Title: Elucidation of roles of Nr4a nuclear orphan receptors and Foxp3 in thymic Treg cell development      
keywords:
Transcriptome or Gene expression
ID:
PRJNA373860
description:
Both Nr4a family nuclear orphan receptors and Foxp3 had been revealed to be crucial transcription factors in Treg cell development. In this study, to reveal their roles in a Treg cell developmental transcriptional programs, we compared transcriptomes among wild-type conventional CD4 T (Tconv) cells, wild-type Treg cells, Nr4a-triple-knockout (Nr4a-TKO) Treg precursor (preTreg) cells, and Foxp3-KO preTreg cells by microarray. Overall design: Total RNA was extracted from wild-type Tconv (CD4-single positive (CD4SP),CD25-low) thymocytes, wild-type thymic Treg (CD4SP, Foxp3+), Nr4a-TKO preTreg (CD4SP, CD25-high, GITR-high, Nr4a3-high), and Foxp3-KO preTreg (CD4SP, CD25high, Foxp3-reporter+) cells. Each cell population was analyzed with two biological replicates.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA373860
authentication:
none
authorization:
none
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject