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Title: Molecular analyses reveal an inflammatory response in the solid component and cystic fluid of human adamantinomatous craniopharyngioma      
keywords:
Transcriptome or Gene expression
ID:
PRJNA369432
description:
Pediatric adamantinomatous craniopharyngioma (ACP) cyst may be associated with injury to critical neurological structures, such as the hypothalamus, resulting in poor quality of life and shorter lifespan. This work presents evidence that immune actors, both pro-inflammatory and immunomodulatory, and their receptors, are present at unique levels in ACP cyst fluid and tumor tissue, potentially indicating a mechanism underlying cyst growth and tumor invasion of the hypothalamus. Transcriptomic analysis revealed that ACP, when compared to other pediatric brain tumors and nomral brain, harbored overexpression of a number of inflammatory and immunosuppressive genes. Overall design: Gene expression profiles were generated from ACP surgical tumor, and surgical tumors of other common pediatric brain tumor types and normal brain samples (n=110) using Affymetrix HG-U133plus2 chips (Platform GPL570).
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA369432
authentication:
none
authorization:
none
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject